消瘀康胶囊联合三磷酸胞苷二钠治疗脑出血恢复期的临床研究  

Clinical study of Xiaoyukang Capsules combined with cytidine disodium triphosphate in treatment of convalescence from cerebral hemorrhage

作　　者：许西海 高艳 王玉华 董攀 郑立志 XU Xi-hai;GAO Yan;WANG Yu-hua;DONG Pan;ZHENG Li-zhi(Department of Neurosurgery,Cangzhou People’s Hospital,Cangzhou 061000,China;Static Distribution Center,Cangzhou People’s Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市人民医院神经外科,河北沧州061000 [2]沧州市人民医院静配中心,河北沧州061000

出　　处：《现代药物与临床》2022年第4期765-769,共5页Drugs & Clinic

基　　金：沧州市重点研发计划项目(172302085)。

摘　　要：目的探讨消瘀康胶囊联合三磷酸胞苷二钠治疗脑出血恢复期的临床疗效。方法选取2019年11月—2021年12月沧州市人民医院收治的118例脑出血恢复期患者,按照随机数字表法分为对照组和治疗组,每组各59例。对照组患者静脉滴注三磷酸胞苷二钠注射液,20 mg加入5%葡萄糖注射液250 mL中缓慢滴注,1次/d。治疗组在对照组的治疗基础上口服消瘀康胶囊,4粒/次,3次/d。两组连续用药10 d。对比两组临床疗效及症状缓解情况,比较两组美国国立卫生院卒中量表(NIHSS)评分、日常生活活动功能指数(Barthel)评分、白细胞介素-6(IL-6)、脑源性神经营养因子(BDNF)、S100蛋白(S100B)、同型半胱氨酸(Hcy)的变化情况。结果治疗后,治疗组总有效率是98.31%,显著高于对照组的83.05%(P<0.05)。治疗后,治疗组肢体功能障碍、头痛、语言功能障碍、头晕缓解时间均显著短于对照组(P<0.05)。治疗后,两组NIHSS评分较治疗前显著降低,而Barthel评分显著升高(P<0.05);治疗后,治疗组NIHSS评分和Barthel评分改善优于对照组(P<0.05)。治疗后,两组IL-6、S100B、Hcy水平均较治疗前显著降低,而BDNF水平显著升高(P<0.05);治疗后,治疗组血清因子水平改善优于对照组(P<0.05)。结论消瘀康胶囊联合三磷酸胞苷二钠治疗脑出血恢复期疗效较佳,可显著缓解患者临床症状,促进脑神经功能恢复,并能有效降低炎性水平,值得临床借鉴。Objective To investigate the efficacy of Xiaoyukang Capsules combined with cytidine disodium triphosphate in treatment of convalescence from cerebral hemorrhage.Methods A total of 118 patients in the convalescent stage of cerebral hemorrhage in Cangzhou People’s Hospital from November 2019 to December 2021 were selected and divided into control group and treatment group according to random number table method,with 59 cases in each group.Patients in the control group were iv administered with Cytidine Disodium Triphosphate Injection,20 mg was added into 5%Glucose Injection 250 mL slowly,once daily.Patients in the treatment group were po administered with Xiaoyukang Capsules on the basis of the control group,4 grains/time,three times daily.Both groups were treated for 10 d.Clinical efficacy and symptom relief were compared between the two groups.The changes of NIHSS score,Barthel index score,IL-6,BRAIN-derived neurotrophic factor(BDNF),S100 protein(S100B)and homocysteine(Hcy)in both groups were compared.Results After treatment,the total effective rate in the treatment group was 98.31%,significantly higher than that in the control group(83.05%,P<0.05).After treatment,the remission time of limb dysfunction,headache,speech dysfunction,and dizziness in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,NIHSS score was significantly lower than before treatment,while Barthel index score was significantly higher in both groups(P<0.05).After treatment,NIHSS score and Barthel index score in the treatment group were better than those in the control group(P<0.05).After treatment,the levels of IL-6,S100B and Hcy in two groups were significantly decreased compared with before treatment,while the level of BDNF was significantly increased(P<0.05).After treatment,the level of serum factors in the treatment group was better than that in the control group(P<0.05).Conclusion Xiaoyukang Capsules combined with Cytidine Disodium Triphosphate Injection has a good therapeutic effect in t

关 键 词：消瘀康胶囊 三磷酸胞苷二钠注射液 脑出血恢复期 症状缓解情况 美国国立卫生院卒中量表评分 血清因子 

分 类 号：R971[医药卫生—药品]