庆大霉素致大鼠不同程度急性肾损伤后肾脏排泄途径的改变  

Changes in renal excretion after gentamicininduced acute kidney injury in rats

作　　者：陈宇玥 张明康 勾雪艳 ABDULAZIZSaad 武新安[2,3] CHEN Yu-yue;ZHANG Ming-kang;GOU Xue-yan;ABDULAZIZ Saad;WU Xin-an(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;School of Pharmacy,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学药学院,兰州730000 [3]兰州大学第一医院药剂科,兰州730000

出　　处：《兰州大学学报（自然科学版）》2022年第2期239-253,共15页Journal of Lanzhou University(Natural Sciences)

基　　金：The National Natural Science Foundation of China (81960680)。

摘　　要：在庆大霉素诱导的不同程度急性肾损伤大鼠模型静脉注射鸡尾酒转运体标记物,通过对各组大鼠肾脏相关转运蛋白表达水平和血清及尿液中底物浓度变化差异进行综合评价.研究发现,中低剂量组大鼠的肾小球滤过功能代偿性增强,肾小管分泌功能轻度下降;随着损伤程度的加重,大鼠的肾小球滤过及肾小管分泌功能明显降低.75及100 mg/(kg·日)庆大霉素组大鼠血清肌酐、五氟尿嘧啶、呋塞米、二甲双胍及对氨基马尿酸的血药浓度-时间曲线下面积升高,除呋塞米外的各个底物清除率均有不同程度的下降.The rat model for acute kidney injury induced by gentamicin(GEN) was administered intravenously with a cocktail renal marker.Through a comprehensive analysis of the protein expression in the transporter related to tubular secretion and the concentration of substrates in serum and urine at different periods,it was shown that the glomerular filtration function of rats was compensated and the tubular secretion function decreased slightly in 25 and 50 mg/(kgd tubule secretion ·day) GEN groups.With the aggravation of injury,both the glomerular filtration anwere decreased obviously.The area under the concentration-time curve of serum creatinine,5-fluorouracil,furosemide,metformin and p-aminohippurate increased in 75 and 100 mg/(kg·day) GEN groups,and the clearance rate of them decreased in varying degrees except for furosemide.

关 键 词：急性肾损伤 肾小球滤过 肾小管分泌 药物转运体 药代动力学 

分 类 号：O659.1[理学—分析化学]