中药复方外用治疗强直性脊柱炎的用药规律探析  

The exploration and analysis of the medication regularity of external use of traditional Chinese medicine compound in the treatment of ankylosing spondylitis

作　　者：卢桂芳 冯波 陈凯 张瑞瑞 高玉霞 赵琳妍 杨科朋 Lu Guifang

机构地区：[1]浙江中医药大学附属第二医院,310005 [2]浙江省嘉兴市中医医院,310053

出　　处：《浙江临床医学》2022年第4期506-508,512,共4页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2020ZB103);浙江省教育厅一般科研项目(Y201942335)。

摘　　要：目的探讨中药复方外用治疗强直性脊柱炎(AS)的用药规律。方法计算机检索万方、维普、知网三个数据库2010年1月至2020年12月已发表的AS相关文献。应用Excel 2010统计分析纳入的中药频次、类别、药性、药味及归经等频数及频率情况,采用IBM SPSS Modeler 18.0软件Apriori算法,对使用频次≥7的中药进行关联分析。采用SPSS 25.0统计软件,对使用频次≥7的中药进行系统聚类分析。结果纳入研究的文献共44篇,涉及处方52张、中药103味。其中,使用频次≥6次的中药有29味,药物类别主要为祛风湿、活血化瘀、清热、补虚等;药性以温为主,平、寒、微寒次之;药味以苦、辛、甘味最为多见;药物归经以肝、脾、肾、肺等为主。高频药物关联规则分析显示,常用药物组合有桂枝→羌活、川芎→羌活、桂枝→细辛、乳香→没药等。高频药物系统聚类分析共得到3个聚类方。结论AS的核心病机总属本虚标实,中药复方外用治疗多采用祛风除湿、温经散寒、活血化瘀、补益肝肾等法。Objective To explore the medication regularity of traditional Chinese medicine for external use in the treatment of ankylosing spondylitis(AS).Methods AS related literatures published in Wanfang,VIP and CNKI databases from January 2010 to December 2020 were searched by computer.Excel 2010 was used to analyze the frequency,category,property,taste and meridian of the included Chinese medicine.IBM SPSS Modeler 18.0 software Apriori algorithm was used to conduct association analysis on Chinese medicine with frequency≥7.SPSS 25.0 statistical software was used for systematic clustering analysis of Chinese medicine with frequency≥7.Results A total of 44 literatures were included in the study,involving 52 prescriptions and 103 Chinese medicines.Among them,29 Chinese medicines were used≥6 times,and the main drugs were dispelling wind and dampness,promoting blood circulation and removing stasis,clearing heat and supplementing deficiency.The medicinal properties were mainly warm,followed by flat,cold,mild cold.The most common medicinal flavors are bitter,spicy and sweet.Drug channels mainly include liver,spleen,kidney and lung.Analysis of high-frequency drug association rules showed that commonly used drug combinations were Guizhi→Qianghuo,Chuanxiong→Qianghuo,Guizhi→Xinxi,Ruxiang→Moyao,etc.Three clusters were obtained by high frequency drug system cluster analysis.Conclusion The core pathogenesis of AS is deficiency in origin and enrichment in symptom.The methods of dispelling wind and removing dampness,warming meridian and dispersing cold,promoting blood circulation and removing blood stasis,and tonifying liver and kidney are commonly used in the external treatment of AS.

关 键 词：强直性脊柱炎 中药外用 用药规律 数据挖掘 

分 类 号：R28[医药卫生—中药学]