红景天注射液与芪苈强心胶囊对冠心病心绞痛患者抗氧化应激指标及心功能的影响  

Effects of Dazhu Hongjingtian injection and Qili Qiangxin capsule on antioxidant stress indexes and cardiac function in patients with angina pectoris coronary heart disease

作　　者：李兰霞[1] 王东雁[2] 王蒙[3] 王明[3] 陈振刚[4] 魏静[3] 王丽娜[4] Li Lanxia;Wang Dongyan;Wang Meng;Wang Ming;Cheng Zhengang;Wei Jing;Wang Lina(Department of Pharmacy,People's Hospital of Jiuquan City,Jiuquan 735000,Gansu,China;Department of Traditional Chinese Medicine,People's Hospital of Jiuquan City,Jiuquan 735000,Gansu,China;Department of Geriatrics,People's Hospital of Jiuquan City,Jiuquan 735000,Gansu,China;Department of Function,People's Hospital of Jiuquan City,Jiuquan 735000,Gansu,China)

机构地区：[1]酒泉市人民医院药剂科,甘肃酒泉7350400 [2]酒泉市人民医院中医科,甘肃酒泉735000 [3]酒泉市人民医院老年科,甘肃酒泉735000 [4]酒泉市人民医院功能科,甘肃酒泉735000

出　　处：《中国中西医结合急救杂志》2022年第1期53-56,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：甘肃省中医药管理局科研项目(GZK-2019-48)。

摘　　要：目的 观察大株红景天注射液与芪苈强心胶囊对冠心病心绞痛患者抗氧化应激指标〔超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)〕、血液流变学及心功能的影响.方法 选择2019年1月至2020年12月酒泉市人民医院收治的80例冠心病心绞痛患者作为研究对象,按治疗方法不同分为常规治疗组和中药治疗组,每组40例.常规治疗组给予西医常规用药如硝酸酯类药物、抗血小板扩张等综合治疗;中药治疗组在西医常规治疗基础上给予中药大株红景天注射液与芪苈强心胶囊.采用酶联免疫吸附试验(ELISA)检测血中SOD、GSH-Px、髓过氧化物酶(MPO)、基质金属蛋白酶-9(MMP-9);采用免疫透射比浊法测定超敏C-反应蛋白(hs-CRP);采用免疫荧光法检测血液流变学指标,使用多普勒超声系统测定心功能指标〔左室射血分数(LVEF),左室收缩期末容积(LVESV)及左室舒张期末压力(LVEDP)〕.比较两组治疗总有效率以及治疗前后上述指标的差异.结果 ① 中药治疗组总有效率较常规治疗组明显提高〔95.0%(38/40)比72.5%(29/40),P<0.05〕.② 两组治疗后血清SOD、GSH-Px均较治疗前升高,且中药治疗组明显高于常规治疗组〔SOD(kU/L):70.21±10.32比53.31±0.18,GSH-Px(g/L):55.32±1.34比38.07±9.06,均P<0.05〕;两组治疗后MPO、MMP-9、hs-CRP均较治疗前降低,且中药治疗组明显低于常规治疗组〔MPO(mmol/L):18.63±2.52比42.11±0.25,MMP-9(mmol/L):42.63±7.22比85.12±0.81,hs-CRP(mg/L):3.91±0.12比6.51±4.32,均P<0.05〕;治疗后两组全血高切黏度、血浆黏度、纤维蛋白原、红细胞聚集指数、血小板聚集指数均明显降低.③ 治疗后两组LVEF均较治疗前升高,LVESV、LVEDP均较治疗前降低,且中药治疗组改善程度较常规治疗组明显〔LVEF:0.49±0.01比0.44±0.00,LVESV(mL/m^(2)):78.13±32.06比99.24±29.35,LVEDP(mmHg,1 mmHg≈0.133 kPa):15.25±2.09比19.85±2.13,均P<0.05〕.结论 大株红景天注射液联用芪苈强心�Objective To observe the effects of Dazhu Hongjingtian injection and Qili Qiangxin capsule on antioxidant stress indexes[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)],hemorheology and cardiac function in patients with angina pectoris coronary heart disease.Methods The 80 patients with coronary heart disease and angina pectoris treated in People's Hospital of Jiuquan City from January 2019 to December 2020 were selected as research objects.They were divided into a conventional treatment group and a traditional Chinese medicine(TCM)treatment group according to the diflerenee in treatment methods,with 40 cases in each group.The conventional treatm ent group was given conventional Western medicine,such as nitrates,anti-platelet,vascular dilatation and other comprehensive treatment,and the TCM treatment group was given Dazhu Hongjingtian injection and Qili Qiangxin capsule on the basis of conventional Western treatment.SOD,GSH-Px,myeloperoxidase(MPO)and matrix metalloproteinase-9(MMP-9)were detected by enzyme linked immunosorbent assay(ELISA),high sensitivity C-reactive protein(hs-CRP)was measurefl by immunity transmission turbidimetry,hemorheological indexes were detected by immunofluorescence,and cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic pressure(LVEDP)]were measured by Doppler ultrasound system.The total therapeutic effective rate and the differences of above indexes before and after treatment were compared hetween the two groups.Results①The total effective rate in the TCM treatment group was significantly higher than that in the conventional treatment group[95.0%(38/40)vs.72.5%(29/40),P<0.05].②After treatment,the levels of serum SOD and GSH-Px in the two groups were higher than those before treatment,and the levels in TCM treatment groi were significantly higher than those in the conventional treatment group[SOD(kU/L):70.21±10.32 vs.53.31±0.18,GSH-Px(g/L):55.32±1.34 vs.38.07±9.06,both P<0.05];a

关 键 词：冠心病心绞痛 大株红景天注射液 芪苈强心胶囊 超氧化物歧化酶 谷胱甘肽过氧化酶 心功能 

分 类 号：R54[医药卫生—心血管疾病]