调节性T细胞在调控抗结核免疫过程中的研究进展  

Progress of regulatory T cells in the regulation of anti-tuberculosis immunity

作　　者：李浩然 姚丛[2] 李珊珊 王伟[1] 逄宇 Li Haoran;Yao Cong;Li Shanshan;Wang Wei;Pang Yu(Department of Bacteriology and Immunology,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China;Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院细菌免疫室,北京101149 [2]首都医科大学附属北京胸科医院北京市耐药结核病重点实验室,北京101149

出　　处：《中华结核和呼吸杂志》2022年第5期502-509,共8页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：北京市医院管理中心“登峰”人才培养计划(DFL20191601);北京市医院管理中心“扬帆”专业建设(ZYLX202122)。

摘　　要：结核分枝杆菌(MTB)作为一种胞内寄生菌,主要通过飞沫传播侵入人体,可导致人体多器官感染从而引起机体产生以T细胞为主导的抗结核免疫应答。调节性T细胞(Treg细胞)作为一类负向调节机体免疫反应的T淋巴细胞亚群,在宿主抗结核免疫中发挥着调控免疫平衡的重要作用。大量研究表明MTB特异性Treg细胞影响着结核病的发生、发展以及疫苗的效能。因此,阐明MTB特异性Treg细胞的抗结核免疫应答的作用及调控机制将有助于进一步揭示宿主抗MTB免疫细胞功能降低的机制,可为结核病的免疫治疗研究提供依据。本文简要介绍了Treg细胞的亚型与功能,对其在结核病领域的研究进展进行了综述。Mycobacterium tuberculosis(MTB),as an intracellular parasitic bacterium,invades the human body mainly through droplets,which can lead to multiple organ infection,causing the body to produce T cell-dominated immunity to tuberculosis(TB).Regulatory T cells(Tregs),as a class of T lymphocyte subsets that negatively regulate the immune response of the body,play an important role in regulating immune balance in host anti-tuberculosis immunity.A large number of studies have shown that MTB-specific Tregs affects the occurrence and development of tuberculosis and the efficacy of the vaccine.Therefore,elucidating the role and regulatory mechanism underlying anti-MTB immune response of MTB-specific Tregs will help to further understanding of the decrease of host anti-MTB immune cell function,and provide a basis for the study of immunotherapy of TB.This paper briefly introduces the subtypes and functions of Tregs,and systematically reviews the research progress of Tregs in many fields of TB.

关 键 词：TREG细胞 机体免疫反应 抗结核免疫 飞沫传播 胞内寄生菌 调节性T细胞 T淋巴细胞亚群 免疫治疗 

分 类 号：R52[医药卫生—内科学]