气道微生态与哮喘气道免疫反应研究进展  

Research progress of airway microbiome and airway immune response in asthma

作　　者：郑莉英 黄丹辉 苏晓芳 蔡绍曦[1] 董航明[1] Zheng Liying;Huang Danhui;Su Xiaofang;Cai Shaoxi;Dong Hangmin(Department of Respiratory and Critical Care Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院呼吸与危重症医学科,广州510515

出　　处：《中华结核和呼吸杂志》2022年第5期519-524,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：支气管哮喘(简称哮喘)是最常见的慢性气道疾病之一,全球3亿多人患有哮喘。近年来,有研究表明,与健康人相比,哮喘患者的气道微生态结构以及各菌群的相对丰度均发生了改变,且与哮喘气道炎症表型相关。气道微生态可以通过免疫反应影响哮喘的发生发展。气道微生态与哮喘相互作用的机制可以为哮喘精准治疗提供新的思路。本文主要对目前气道微生态在哮喘中的研究进行综述,并对未来哮喘的精准治疗提出展望。Bronchial asthma(asthma)is one of the most common chronic airway diseases,with more than 300 million people worldwide suffering from this disease.In recent years,studies have shown that compared with healthy people,the airway microecological structure and relative abundance of various flora of asthmatic patients have changed,and are related to the airway inflammatory phenotype of asthma.Airway microecology can affect the occurrence and development of asthma through immune response.The mechanism of interaction between airway microecology and asthma can provide new ideas for the accurate treatment of asthma.This article mainly reviewed the current research on airway microecology in asthma,and puts forward prospects for the accurate treatment of asthma in the future.

关 键 词：精准治疗 免疫反应 支气管哮喘 微生态 哮喘气道炎症 慢性气道疾病 相对丰度 表型相关 

分 类 号：R562.25[医药卫生—呼吸系统]