慢性心理应激通过调控生殖内分泌系统引起雄性生殖受损的研究进展  

The research progress of chronic psychological stress damage male reproduction through regulating reproductive endocrine system

作　　者：张玲羽 高山凤 李如风 汪夏 肖轩 韩林 熊晓蕃 杨娟 ZHANG Lingyu;GAO Shanfeng;LI Rufeng;WANG Xia;XIAO Xuan;HAN Lin;XIONG Xiaofan;YANG Juan(Department of Cell Biology and Genetics,School of Basic Medical Science,Xi'an Jiaotong University Health Science Center,Xi'an,Shaanxi 710061,China;Biomedical Experiment Center,Xi'an Jiaotong University,Health Science Center,Xi'an,Shaanxi 710061,China)

机构地区：[1]西安交通大学医学部基础医学院细胞生物学与遗传学系,陕西西安710061 [2]西安交通大学医学部生物医学实验中心,陕西西安710061

出　　处：《中国优生与遗传杂志》2022年第4期533-541,共9页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81671445)。

摘　　要：社会竞争、工作压力及家庭负担等社会应激逐渐加剧,加重了人们的心理压力。当机体处于长期应激状态下会影响机体内分泌系统的稳定性,可造成神经、代谢、免疫、心血管及生殖系统损伤。流行病学证据证明,抑郁症及创伤后应激障碍等心理应激患者的精液质量明显下降,动物实验也证明心理应激可引发精子生成障碍,损伤精子活性引发男性不育。本文将通过综述慢性心理应激对交感神经-肾上腺系统(SAS)、下丘脑-垂体-肾上腺轴(HPA)及下丘脑-垂体-睾丸轴(HPT)功能的影响而引发生殖内分泌系统紊乱造成的男性不育,阐明心理应激对雄性生殖功能的损伤。Social stress, such as social competition, work pressure and family burden, has gradually intensified, aggravating people’s psychological pressure. Long-term stress will affect the stability of the body’s endocrine system, resulting in neurological, metabolic, immune, cardiovascular and reproductive system damage. Epidemiological evidence has proved that the semen quality of patients with psychological stress such as depression and post-traumatic stress disorder decreases significantly.Animal experiments have also proved that psychological stress can cause spermatogenesis disorder, damage sperm activity and lead to male infertility. In this paper, we will review the effects of chronic psychological stress on the sympathetic-adrenal system(SAS), hypothalamic-pituitary-adrenal axis(HPA) and hypothalamic-pituitary-testicular axis(HPT), which lead to male infertility caused by reproductive endocrine system disorder, and clarify the damage of psychological stress on male reproductive function.

关 键 词：心理应激 生殖内分泌系统 雄性生殖损伤 

分 类 号：R339.21[医药卫生—人体生理学]