中药中寡糖分离分析方法研究进展  

Research advance in separation and analysis of oligosaccharides from traditional Chinese medicine

作　　者：刘妍妍 刘建飞[2] 邢连喜[3,4] 邸多隆 LIU Yan-yan;LIU Jian-fei;XING Lian-xi;DI Duo-long(School of Pharmacy,Gansu University of Chinese Medicine;Key Laboratory of Chemistry of Northwestern Plant Resources/Key Laboratory of Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;College of Life Sciences,Northwest University;Shaanxi Functional Food Engineering Center Co.,Ltd.,Xi'an 710069,China)

机构地区：[1]甘肃中医药大学药学院 [2]中国科学院兰州化学物理研究所中国科学院,西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室,兰州730000 [3]西北大学生命科学学院,西安710069 [4]陕西功能食品工程中心有限公司,西安710000

出　　处：《天然产物研究与开发》2022年第5期887-898,共12页Natural Product Research and Development

基　　金：国家自然科学基金(21904130)。

摘　　要：糖链结构与功能研究是未来糖生物学研究的重要方向,必将为人类疾病的研究和治疗带来新的希望。随着对糖类研究的不断深入,寡糖因其所具有的多种药理活性受到了国内外学者的广泛关注。寡糖结构受连接位点、糖环结构和分支等因素的影响而呈现复杂性和多样性,这为其提取,纯化、分离分析以及结构表征带来巨大了挑战。本文综述了近年来国内外在中药寡糖提取纯化、分离分析以及结构表征这三方面的研究内容,以期为寡糖的现代药物研究和临床应用以及功效产品创制提供科学参考。The research of oligosaccharides chains and function are important directions of glycobiology research in the future,which will bring new hope to the research and treatment of human diseases.With deep research on carbohydrates,oligosaccharide have attracted extensive attention of scholars at home and abroad in recent years because of their various pharmacological activities.The structure of oligosaccharide is complex and diverse influenced by linkage site,sugar ring structure and branch,which bring great challenges to its extraction,purification,separation analysis and structural characterization.This article summarized domestic and foreign researches on extraction,purification,separation and analysis,and structural characterization of traditional Chinese medicine on oligosaccharides in recent years,and in order to provide a reference for modern drugs research,clinical applications of oligosaccharides and the creation of functional products.

关 键 词：中药 寡糖 分离分析 

分 类 号：R917[医药卫生—药物分析学]