香砂六君子汤加味联合化疗治疗肺脾气虚型小细胞肺癌60例临床观察  

Clinical Observation on 60Cases of Lung Spleen Qi Deficiency Small Cell Lung Cancer Treated with Modified Xiangsha Liujunzi Decoction Combined with Chemotherapy

作　　者：叶少毅 Ye Shaoyi(Oncology Department,Zhangzhou Hospital of Traditional Chinese Medicine,Zhangzhou 363000,China)

机构地区：[1]漳州市中医院肿瘤科,福建漳州363000

出　　处：《亚太传统医药》2022年第5期84-88,共5页Asia-Pacific Traditional Medicine

摘　　要：目的:探讨香砂六君子汤加味联合化疗治疗肺脾气虚型小细胞肺癌(SCLC)患者的临床疗效。方法:选取60例肺脾气虚型SCLC患者作为研究对象,根据数字奇偶法将其分为对照组与观察组,每组各30例。对照组给予常规化疗治疗,观察组在此基础上联合香砂六君子汤加味治疗,以3周为1个治疗周期,连续治疗3周期后比较两组患者临床疗效、体力状况及生活质量,并记录两组患者化疗期间毒副反应发生情况。用药结束后以门诊或电话等方式进行随访,随访至2021年1月或患者死亡,记录两组患者中位生存期,及第1、2、3年生存率。结果:观察组治疗3个周期后治疗总有效率(63.33%)高于对照组(36.67%),P<0.05;治疗3个周期后两组患者体力状况、生活质量评分均有提高,且观察组体力状况、生活质量评分均高于对照组(P<0.05);观察组Ⅲ~Ⅳ级恶心呕吐、血小板减少、白细胞减少、肝肾功能损害以及腹泻便秘等不良反应发生率(23.33%)低于对照组(50.00%),P<0.05;观察组中位生存期长于对照组,第1、2、3年生存率均高于对照组(P<0.05),经Lon-rank检验发现两组患者生存曲线具有统计学意义(P<0.05)。结论:香砂六君子汤加味联合化疗治疗肺脾气虚型SCLC患者可提高化疗效果及生存率,改善生活质量。Objective:Objective:To investigate the clinical efficacy of Xiangsha Liujunzi Decoction Combined with chemotherapy in the treatment of lung spleen qi deficiency small cell lung cancer(SCLC).Methods:60patients with lung spleen qi deficiency SCLC treated in our hospital from January 2017to January 2018were selected as the research object.According to the digital parity method,they were divided into control group and observation group,with 30cases in each group.The control group was treated with conventional chemotherapy,and the observation group was treated with Xiangsha Liujunzi Decoction for 3weeks.After 3consecutive cycles,the clinical efficacy,physical condition and quality of life of the two groups were compared,and the occurrence of toxic and side effects during chemotherapy were recorded.The patients were followed up by outpatient service or telephone until January 2021or death.The median survival time and 1,2and 3year survival rates of the two groups were recorded.Results:After 3cycles of treatment,the total effective rate in the observation group was higher than that in the control group(63.33%vs 36.67%,P<0.05);After 3cycles of treatment,the scores of physical condition and quality of life in the two groups were improved,and the scores of physical condition and quality of life in the observation group were higher than those in the control group(P<0.05);The incidence of gradeⅢ-IV nausea and vomiting,thrombocytopenia,leucopenia,liver and kidney function damage,diarrhea and constipation in the observation group was lower than that in the control group(23.33%vs 50.00%,P<0.05);The median survival time of the observation group was longer than that of the control group,and the 1,2 and 3-year survival rates were higher than those of the control group(P<0.05).Lon rank test showed that the surviv-al curve of the two groups was statistically significant(P<0.05).Conclusion:Xiangsha Liujunzi Decoction Combined with chemotherapy in the treatment of SCLC patients with lung spleen qi deficiency can improve the effect of

关 键 词：小细胞肺癌 肺脾气虚型 香砂六君子汤加味联合化疗 临床观察 

分 类 号：R243[医药卫生—中医临床基础]