DBEncRNA:细菌必需非编码RNA数据库  

DBEncRNA:Database of Bacterial Essential ncRNA

作　　者：叶远浓 梁定发[1] 曾柱 YE Yuannong;LIANG Dingfa;ZENG Zhu(School of Big Health,Guizhou Medical University Guiyang 550025;Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University Guiyang 550025)

机构地区：[1]贵州医科大学大健康学院,贵阳550025 [2]贵州医科大学环境污染监测与疾病控制教育部重点实验室,贵阳550025

出　　处：《电子科技大学学报》2022年第3期348-352,共5页Journal of University of Electronic Science and Technology of China

基　　金：国家自然科学基金(61803112,32160151);贵州省科技支撑计划(黔科合支撑[2019]2811号)。

摘　　要：细菌非编码RNA(non-coding RNA,ncRNA)是近年来在细菌基因组内新发现的一类基因表达调控因子,与必需基因概念类似,有一部分ncRNA是生物体生存所必不可少的,称之为“必需非编码RNA”。因此,细菌的必需ncRNA可以作为药物开发的潜在靶标,以降低致病菌的耐药性。同时,必需ncRNA也成为最小基因组研究的重要对象之一。目前已经通过湿实验系统地确定了10余种细菌的必需ncRNA,然而还没有一个专门的必需ncRNA数据库,导致对必需ncRNA的研究远远跟不上科学研究和药物设计的需要。因此,该研究构建了一个专门的细菌必需ncRNA数据库DBEncRNA,以帮助研究人员开发高效的必需ncRNA计算机识别方法,用于进一步研究抗菌药物靶标发现和最小基因组。DBEncRNA数据库可以通过http://yeyn.group:86/免费访问使用。Bacterial non-coding RNA(ncRNA)is a class of gene expression regulators in bacteria in recent years.Similar to the concept of essential genes,a part of ncRNA is indispensable for the survival of organisms,which is called essential ncRNA.Therefore,the bacterial essential ncRNAs could be used as potential targets for drug development in order to reduce drug resistance in pathogenic bacteria.The essential ncRNA has become one of the important objects of minimal genome research.At present,the essential ncRNAs of more than a dozen bacteria have been systematically identified by experimental method.However,there is no specialized essential ncRNAs database.And hence,the research on essential ncRNAs is far behind the needs of scientific research and drug design.In consequence,in this study,a special database of bacterial essential ncRNA(DBEncRNA)is proposed and constructed to help researchers develop the efficient recognition methods for essential ncRNA in silico,for further studies including antimicrobial target discovery and minimal genome research.The DBEncRNA database can be accessed by http://yeyn.group:86/freely.

关 键 词：抗菌药物靶标 数据库 必需非编码RNA 最小基因组 致病菌 

分 类 号：TP391[自动化与计算机技术—计算机应用技术] Q615[自动化与计算机技术—计算机科学与技术]