尿促性素联合枸橼酸氯米芬治疗多囊卵巢综合征不孕症患者的效果  

Effects of urinary gonadotropin combined with Clomiphene citrate in treatment of infertility patients with polycystic ovary syndrome

作　　者：宁伟 NING Wei(Department of Obstetrics and Gynecology of Maternal and Child Health Hospital of Pingqiao District of Xinyang City,Xinyang 464000 Henan,China)

机构地区：[1]信阳市平桥区妇幼保健院妇产科,河南信阳464000

出　　处：《中国民康医学》2022年第8期49-51,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察尿促性素联合枸橼酸氯米芬治疗多囊卵巢综合征(PCOS)不孕症患者的效果。方法:选取100例PCOS不孕症患者为研究对象,按照随机数字表法分为观察组与对照组各50例。对照组给予枸橼酸氯米芬治疗,观察组在对照组基础上给予尿促性素治疗,比较两组临床疗效、雌二醇(E2)水平、促黄体生成素(LH)水平、睾酮(T)水平、妊娠率、早期流产率、多胎妊娠率和卵巢过度刺激综合征发生率。结果:观察组治疗总有效率为96.00%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组E2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组LH、T水平比较,差异无统计学意义(P>0.05);随访1年,观察组妊娠率为52.00%,明显高于对照组的30.00%,差异有统计学意义(P<0.05);两组早期流产率、多胎妊娠率和卵巢过度刺激综合征发生率比较,差异均无统计学意义(P>0.05)。结论:尿促性素联合枸橼酸氯米芬治疗PCOS不孕症患者可提高治疗总有效率、E2水平和临床妊娠率,效果优于单纯枸橼酸氯米芬治疗。Objective: To observe effects of urinary gonadotropin combined with Clomiphene citrate in treatment of infertility patients with polycystic ovary syndrome(PCOS). Methods: 100 infertile patients with PCOS were selected as the research objects and were divided into observation group and control group according to the random number table method, 50 cases in each group. The control group was given Clomiphene citrate treatment, while the observation group was treated with urinary gonadotropin treatment on the basis of that of the control group. The clinical effects, the estradiol(E;) level, the luteinizing hormone(LH) level, the testosterone(T) level, the pregnancy rate, the early miscarriage rate, the multiple pregnancy rate and the incidence of ovarian hyperstimulation syndrome were compared between the two groups. Results: The total effective rate of the observation group was 96.00%, which was significantly higher than 80.00% of the control group, and the difference was statistically significant(P<0.05). After the treatment, E;levels in the two groups were higher than before the treatment, that of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). After the treatment, there were no significant differences in the LH and T levels between the two groups(P>0.05). After 1 year of follow-up, the pregnancy rate of the observation group was 52.00%, which was significantly higher than the control group of 30.00%, and the difference was statistically significant(P<0.05). Further, there were no significant difference in the early miscarriage rate, the multiple pregnancy rate and the incidence of ovarian hyperstimulation syndrome between the two groups(P>0.05). Conclusions: Urinary gonadotropin combined with Clomiphene citrate in the treatment of the infertile patients with PCOS can improve the total effective rate, the E;level and the clinical pregnancy rate. Moreover, it is superior to single Clomiphene citrate treatment.

关 键 词：尿促性素 枸橼酸氯米芬 多囊卵巢综合征 性激素 妊娠 

分 类 号：R588.6[医药卫生—内分泌]