超脉冲CO_(2)点阵激光联合0.5%马来酸噻吗洛尔滴眼液外敷治疗婴幼儿皮肤血管瘤的效果  

Effects of ultra-pulsed CO_(2) fractional laser combined with 0.5% Timolol maleate eye drops external application in treatment of infantile cutaneous hemangioma

作　　者：孟小卉 李舒[1] MENG Xiaohui;LI Shu(Department of Dermatology of the 7th People’s Hospital of Zhengzhou,Henan 450000 Zhengzhou,China)

机构地区：[1]郑州市第七人民医院皮肤科,河南郑州450000

出　　处：《中国民康医学》2022年第8期55-58,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察超脉冲CO_(2)点阵激光联合0.5%马来酸噻吗洛尔滴眼液外敷治疗婴幼儿皮肤血管瘤的效果。方法:选取94例皮肤血管瘤患儿为研究对象,按照随机数字表法分为观察组与对照组各47例。对照组采用0.5%马来酸噻吗洛尔滴眼液外敷治疗,观察组在对照组基础上采用超脉冲CO_(2)点阵激光治疗,比较两组临床疗效、碱性成纤维细胞生长因子(bFGF)水平、血管内皮细胞生长因子(VEGF)水平、病灶厚度和不良反应发生率。结果:观察组治疗总有效率为93.62%,高于对照组的78.72%,差异有统计学意义(P<0.05);治疗后,两组bFGF、VEGF水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组病灶厚度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:超脉冲CO_(2)点阵激光联合0.5%马来酸噻吗洛尔滴眼液外敷治疗婴幼儿皮肤血管瘤可提高治疗总有效率,降低病灶厚度及bFGF和VEGF水平,效果优于单纯0.5%马来酸噻吗洛尔滴眼液外敷治疗。Objective: To observe effects of ultra-pulsed CO_(2) fractional laser combined with 0.5% Timolol maleate eye drops external application in treatment of infantile cutaneous hemangioma. Methods: 94 infants with cutaneous hemangioma were selected as the research objects and were divided into observation group and control group according to the random number table method, 47 cases in each group. The control group was treated with 0.5% Timolol maleate eye drops external application, while the observation group was treated with ultra-pulsed CO_(2) fractional laser treatment on the basis of that of the control group. The clinical efficacy, the basic fibroblast growth factor(bFGF) level, the vascular endothelial growth factor(VEGF) level, the lesion thickness and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate of children in the observation group was 93.62%, which was higher than 78.72% in the control group, and the difference was statistically significant(P<0.05). After the treatment, the levels of bFGF and VEGF in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). After the treatment, the lesion thickness levels in the two groups were lower than those before the treatment;that of the observation group was lower than that of the control group;and the difference was statistically significant(P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Ultra-pulsed CO_(2) fractional laser combined with 0.5% Timolol maleate eye drops external application in the treatment of infantile cutaneous hemangioma can improve the total effective rate and reduce the lesion thickness as well as the bFGF and VEGF levels. Moreover, it is superior to single 0.5% Timolol maleate eye drops external application.

关 键 词：婴幼儿皮肤血管瘤 超脉冲CO_(2)点阵激光 0.5%马来酸噻吗洛尔滴眼液 血管内皮细胞生长因子 病灶厚度 不良反应 

分 类 号：R543[医药卫生—心血管疾病]