黄芪注射液辅助治疗脓毒症患者的效果  

Effects of Astragalus injection in adjuvant treatment of patients with sepsis

作　　者：王敏慧 许石钟[1] WANG Minhui;XU Shizhong(Department of Pharmacy of Puyang Hospital of Traditional Chinese Medicine,Puyang 457001 Henan,China)

机构地区：[1]濮阳市中医院药剂科,河南濮阳457001

出　　处：《中国民康医学》2022年第8期99-101,105,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察黄芪注射液辅助治疗脓毒症患者的效果。方法:选取78例脓毒症患者为研究对象,按照随机数字表法分为研究组与对照组各39例。对照组给予常规治疗,研究组在对照组基础上给予黄芪注射液治疗,比较两组有创通气时间、无创通气时间、入住ICU时间、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、全身性感染相关性器官功能衰竭评价(SOFA)评分、T细胞亚群指标(CD3;、CD3;CD4;、CD3;CD8;)水平、炎性因子[血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6]水平和不良反应发生率。结果:研究组有创通气时间、无创通气时间和入住ICU时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组APACHEⅡ和SOFA评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,研究组CD3;、CD3;CD4;水平均高于对照组,CD3;CD8;水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清TNF-α、IL-1β、IL-6水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上采用黄芪注射液治疗脓毒症患者可缩短有创通气时间、无创通气时间和入住ICU时间,降低APACHEⅡ评分、SOFA评分和炎性因子水平,以及改善T细胞亚群指标水平,效果优于单纯常规治疗。Objective: To observe effects of Astragalus injection in adjuvant treatment of patients with sepsis. Methods: 78 patients with sepsis were selected as the research objects and were divided into study group and control group according to the random number table method, 39cases in each. The control group was given routine treatment, while the study group was given Astragalus injection on the basis of that of the control group. The invasive ventilation time, the non-invasive ventilation time, the ICU stay time, the acute physiology and chronic health status scoring system Ⅱ(APACHE Ⅱ) score, the sepsis-related organ failure assessment(SOFA) score, the T cell subset index(CD3;, CD3;CD4;, CD3;CD8;),the inflammatory factor levels [serum tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-6] and the incidence of adverse reactions were compared between the two groups. Results: The invasive ventilation time, the non-invasive ventilation time and the ICU stay time in the study group were all shorter than those in the control group, and the differences were statistically significant(P<0.05). After the treatment, the APACHE Ⅱ and SOFA scores of the two groups were lower than those before the treatment;those of the study group were lower than those of the control group;and the differences were statistically significant(P<0.05). After the treatment, the levels of CD3;and CD3;CD4;in the study group were higher than those in the control group;the level of CD3;CD8;was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment, the serum levels of TNF-α, IL-1β, and IL-6 in the two groups were lower than those before the treatment;those of the study group were lower than those of the control group;and the differences were statistically significant(P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: On the basis of the routine treatment, Astragalus injection in the treatment o

关 键 词：黄芪注射液 脓毒症 T细胞亚群 APACHEⅡ评分 SOFA评分 炎性因子 不良反应 

分 类 号：R631[医药卫生—外科学]