血清E2、P、VEGF及子宫内膜厚度在异位妊娠早期诊断中的应用  

Application of serum E2,P,VEGF and endometrial thickness in early diagnosis of ectopic pregnancy

作　　者：邹丹 周素芳[1] 赵爱琴[1] 张小燕[1] ZOU Dan;ZHOU Sufang;ZHAO Aiqin;ZHANG Xiaoyan(Department of Obstetrics&Gynecology,Jiangsu Suzhou High Tech Zone People's Hospital,Suzhou,Jiangsu,China,215129)

机构地区：[1]苏州高新区人民医院妇产科,江苏苏州2151129

出　　处：《分子诊断与治疗杂志》2022年第4期627-630,共4页Journal of Molecular Diagnostics and Therapy

基　　金：苏州高新区人民医院院管科研(SYSD2015065)。

摘　　要：目的探究血清雌二醇(E2)、孕酮(P)、血管内皮生长因子(VEGF)及子宫内膜厚度在异位妊娠的水平变化及临床诊断价值。方法选取2019年5月至2021年5月苏州高新区人民医院妇产科收治的疑似异位妊娠孕妇114例为研究对象,其中经病理学或手术检查确诊的79例为病例组,其他35例为对照组。比较两组孕妇血清E2、P、VEGF水平差异,并使用彩色多普勒超声仪测定两组孕妇的子宫内膜厚度,以ROC曲线分析各项指标单独或联合诊断早期异位妊娠的价值。结果病例组孕妇的血清E2、P及子宫内膜厚度低于对照组,VEGF水平显著高于对照组,差异均有统计学意义(t=7.654,P<0.05)。二元Logistic分析显示,E2、P水平降低,VEGF水平升高及子宫内膜厚度降低均为异位妊娠的危险因素(P<0.05)。ROC显示,E2、P、VEGF、子宫内膜厚度对异位妊娠诊断的AUC分别为0.795、0.904、0.838、0.861,四项联合检测的AUC为0.978,敏感度、特异度为100%、85.7%,优于单一检测(P<0.05)。结论异位妊娠孕妇血清E2、P、VEGF检测及子宫内膜厚度的检查对疾病的早期诊断具价值较高,四者联合诊断的敏感度及特异性更高。Objective To explore the application value of serum estradiol(E2),progesterone(P),vascular endothelial growth factor(VEGF)and endometrial thickness in the early diagnosis of ectopic pregnancy.Methods A total of 114 pregnant women with suspected early ectopic pregnancy who were admitted to the Department of Obstetrics and Gynecology,Suzhou High⁃tech Zone People's Hospital from May 2019 to May 2021 were selected as the research objects,of which 79 cases were confirmed by pathological or surgical examination as the case group,and the other 35 cases for the control group.The differences in serum E2,P,and VEGF levels of the two groups of pregnant women were detected,and the endometrial thickness of the two groups of pregnant women was measured by Color Doppler ultrasound.The ROC curve was used to analyze the value of each index alone or in combination in diagnosing early ectopic pregnancy.Results The serum E2,P and endometrial thickness of pregnant women in the case group were lower than those in the control group,while the level of VEGF was significantly higher than that in the control group(P<0.05).Binary Logistic analysis showed that decreased E2 and P levels,increased VEGF level and decreased endometrial thickness were risk factors for ectopic pregnancy(P<0.05).The results of ROC curve showed that the AUC of E2,P,VEGF,and endometrial thickness for the diagnosis of ectopic pregnancy were 0.795,0.904,0.838,and 0.861,respectively.The AUC of the four combined detection was 0.978,and the sensitivity and specificity were 100%and 85.7%,better than single detection(P<0.05).Conclusion The detection of serum E2,P,VEGF and endometrial thickness in ectopic pregnancy and puerperium have higher value for the early diagnosis of the disease,and the sensitivity and specificity of the combination of the four are higher.

关 键 词：异位妊娠 子宫内膜厚度 雌二醇 孕酮 血管内皮生长因子 

分 类 号：R714.22[医药卫生—妇产科学]