老年高血压NSF⁃1、25(OH)D及Hcy水平与骨质疏松的关系  

Relationship between NSF⁃1,25(OH)D and Hcy levels and osteoporosis in elderly hypertensive patients

作　　者：周亚捷 姚反修[2] 杨默 罗晓华[2] 韩晓霞[1] 李安琪[2] 曹婷婷[2] ZHOU Yajie;YAO Fanxiu;YANG Mo;LUO Xiaohua;HAN Xiaoxia;LI Anqi;CAO Tingting(Department of Nursing,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450000;Department of Geriatrics,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州大学第五附属医院护理部,河南郑州450000 [2]郑州大学第五附属医院老年科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2022年第4期673-676,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技功关计划联合共建项目(LHGJ20190411)。

摘　　要：目的探讨老年高血压摄食抑制因子⁃1(NSF⁃1)、25羟基维生素D[25⁃(OH)D]、同型半胱氨酸(Hcy)水平与骨质疏松的关系。方法选取2018年5月至2020年4月郑州大学第五附属医院收治的157例老年高血压患者,根据骨密度分为骨量正常组、骨量减少组以及骨质疏松组。比较三组NSF⁃1、25(OH)D、Hcy以及不同部位BMD水平;分析老年高血压患者NSF⁃1、25(OH)D、Hcy水平与BMD的相关性。结果三组NSF⁃1、Hcy水平比较:骨质疏松组>骨量减少组>骨量正常组,三组25(OH)D水平及股骨颈、L1~L4的BMD比较:骨质疏松组<骨量减少组<骨量正常组,差异均有统计学意义(P<0.05)。经Spearman分析得出,老年高血压患者NSF⁃1、Hcy水平与股骨颈及L1~L4的BMD呈负相关(P<0.05),25(OH)D水平与股骨颈及L1~L4的BMD呈正相关(P<0.05)。结论老年高血压患者NSF⁃1、25(OH)D、Hcy水平与骨质疏松风险增加存在明显的相关性,临床工作者可通过加强监测上述三项指标,以助于及时指导患者进行预防和诊治,降低骨质疏松发生的风险。Objective To investigate the relationship between the feeding inhibitory Nesfatin⁃1(NSF⁃1),25⁃Hydroxy vitamin D(25⁃(OH)D),and homocysteine(Hcy)levels and osteoporosis in elderly hypertensive patients.Methods 157 elderly hypertensive patients admitted to the Fifth Affiliated Hospital of Zhengzhou University from May 2018 to April 2020 were selected,according to the bone mineral density,they were divided into the normal bone mass group,the osteopenia group and the osteoporosis group.The levels of NSF⁃1,25(OH)D,Hcy and BMD in different parts of the three groups were compared;the correlation between the levels of NSF⁃1,25(OH)D,Hcy and BMD in elderly hypertensive patients was analyzed.Results Comparison of NSF⁃1 and Hcy levels in the three groups:osteoporosis group>osteopenia group>normal bone mass group,comparison of 25(OH)D levels and BMD of femoral neck and L1⁃L4 in the three groups:osteoporosis Group<Bone loss group<Normal bone mass group,the differences were all statistically significant(P<0.05).Spearman analysis showed that the levels of NSF⁃1 and Hcy in elderly hypertensive patients were negatively correlated with the BMD of the femoral neck and L1⁃L4(P<0.05),and the 25(OH)D level was positively correlated with the BMD of the femoral neck and L1⁃L4.Correlation(P<0.05).Conclusion The levels of NSF⁃1,25(OH)D,Hcy in elderly hypertensive patients are significantly correlated with the increased risk of osteoporosis.Clinicians can strengthen monitoring of above three indicators in elderly hypertensive patients to help timely guidance patients for prevention and diagnosis,and reduce the risk of osteoporosis.

关 键 词：老年高血压 NSF⁃1 骨质疏松 25(OH)D HCY 

分 类 号：R580[医药卫生—内分泌] R544.1[医药卫生—内科学]