病证结合模式下中医证候疗效评价量表研制的实践与策略  

Strategy and Development of the TCM Syndrome-based Treatment Effectiveness Assessment Scale Using the Mode of Combination of Disease and Syndrome

作　　者：李建生[1,2] 冯贞贞[1,2] 谢洋[1,2] 王佳佳[1,2] LI Jiansheng;FENG Zhenzhen;XIE Yang;WANG Jiajia(Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province&Education Ministry of P.R.China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,河南省中医药防治呼吸病重点实验室,河南省郑州市450046 [2]河南中医药大学第一附属医院,河南省郑州市450000

出　　处：《中国全科医学》2022年第20期2513-2519,共7页Chinese General Practice

基　　金：国家自然科学基金资助项目(81830116);河南省重点研发与推广专项(科技攻关)项目(212102310361);中医药传承与创新“百千万”人才工程—岐黄工程首席科学家(国中医药人教函[2020]219号)。

摘　　要：证候疗效评价量表可为客观评价中医证候疗效提供依据,丰富中医临床疗效评价体系。目前尚缺乏统一、规范的证候疗效评价量表研制方法。借鉴国际量表研制规范及中医量表研究思路,依据中医证候特点,基于已研制的慢性阻塞性肺疾病稳定期证候疗效评价量表(COPD-STES),初步提出中医证候疗效评价量表研制基本流程及关键技术,包括7个主要环节(成立研究小组、预设量表基本特征、构建理论框架及条目池、筛选条目、初步形成量表、确定条目权重及量表的考核)、3项关键技术(基于关联规则及隐结构分析的数据挖掘技术,基于经典测量理论与项目反应理论的条目筛选方法,基于随机森林法、因子分析法及百分权重法的条目赋权法),可为其他相关研究提供参考。The TCM-based syndrome treatment effectiveness assessment scale could provide a basis for objectively evaluating the effectiveness of syndrome-based treatment and enrich the evaluation system of TCM treatment results.There are no unified and standardized methods for developing this kind of scale.In accordance with the international standards for developing a scale and ideas for developing a scale for assessing TCM treatment results as well as features of the TCM syndrome,and the experience of developing Syndrome Therapeutic Evaluation Scale of Chronic Obstructive Pulmonary Disease,we proposed the general process〔including seven main parts(forming a research group,pre-designing the basic characteristics of the scale,constructing a framework and item pool,screening the items,forming a draft form of the scale,determining the weight of the items,and test of the scale),and three key techniques(data mining technology based on association rules and latent structure analysis,item screening based on classical test theory and item response theory,and item weighting based on random forest,factor analysis,and percent weight)〕for developing a TCM-based syndrome treatment effectiveness assessment scale,hoping to offer guidance for other relevant studies.

关 键 词：中医病因和病机 病因证候 治疗结果 慢性阻塞性肺疾病稳定期证候疗效评价量表 病人结局评价 评价方法 

分 类 号：R241.1[医药卫生—中医诊断学]