调胃通腑针法联合西药治疗糖尿病性胃轻瘫的疗效观察及对血清ANO1含量的影响  

Efficacy Observation of Tiao Wei Tong Fu Acupuncture Method Combined with Western Medication in Treating Diabetic Gastroparesis and Its Effect on Serum ANO1 Content

作　　者：任志欣[1] 朱敬云[1] 王琳琳[1] REN Zhixin;ZHU Jingyun;WANG Linlin(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第二附属医院,郑州450000

出　　处：《上海针灸杂志》2022年第5期431-436,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：河南省中医药科学研究专项课题(2015ZYO2056)。

摘　　要：目的观察调胃通腑针法联合西药治疗糖尿病性胃轻瘫(DGP)的临床疗效及对血清跨膜蛋白16A(TMEM16A,又称为ANO1)含量的影响。方法将113例DGP患者作为研究对象,随机分为西药组56例和针刺组57例。两组患者均给予西药控制血糖,西药组给予口服枸橼酸莫沙必利分散片,针刺组在西药组治疗的基础上联合调胃通腑针法。比较两组患者临床疗效,观察两组治疗前后胃轻瘫症状评分、胃肠运动功能、血清胃肠激素及ANO1水平变化。结果两组治疗后胃轻瘫症状评分较治疗前降低(P<0.05),且针刺组低于西药组(P<0.05)。两组患者治疗后0.5 h胃排空率(GER)水平较治疗前升高(P<0.05),且针刺组高于西药组(P<0.05);胃排空时间(GET)、胃半排空时间(T1/2)、180 min胃残留率水平较治疗前降低(P<0.05),且针刺组低于西药组(P<0.05)。两组治疗后血清胃泌素(GAS)、胃动素(MTL)水平较治疗前升高(P<0.05),且针刺组高于西药组(P<0.05);生长抑素(SST)、ANO1水平较治疗前降低(P<0.05),且针刺组低于西药组(P<0.05)。针刺组总有效率为93.0%(53/57)高于西药组的76.8%(43/56)(P<0.05)。结论调胃通腑针法联合枸橼酸莫沙必利分散片可调控DGP患者的胃肠运动功能,改善其胃轻瘫症状,调节胃肠激素水平及血清ANO1含量。Objective To observe the clinical efficacy of Tiao Wei Tong Fu(regulating the stomach to unblock Fu organs)acupuncture method combined with Western medication in treating diabetic gastroparesis(DGP)and its effect on the content of serum transmembrane protein 16A(TMEM16A or ANO1).Method A total of 113 DGP patients were recruited and randomized into a Western medication group of 56 cases and an acupuncture group of 57 cases.Both groups received Western medication for control of blood glucose.In addition,the Western medication group was given oral Mosapride citrate dispersible tablets,and the acupuncture group was offered Tiao Wei Tong Fu acupuncture treatment based on the intervention given to the Western medication group.The clinical efficacy was compared between the two groups.The gastroparesis symptom score,gastrointestinal motility,and serum gastrointestinal hormone and ANO1 levels were observed before and after the treatment.Result The gastroparesis symptom score dropped after the treatment in both groups(P<0.05)and was lower in the acupuncture group than in the Western medication group(P<0.05).After the treatment,the 0.5 h gastric emptying rate(GER)increased in both groups(P<0.05)and was higher in the acupuncture group than in the Western medication group(P<0.05).The gastric emptying time(GET),gastric semi-emptying time(T1/2),and 180 min gastric residual rate decreased after the treatment in both groups(P<0.05)and were lower in the acupuncture group than in the Western medication group(P<0.05).After the treatment,the serum gastrin(GAS)and motilin(MTL)levels increased in the two groups(P<0.05)and were higher in the acupuncture group than in the Western medication group(P<0.05).The levels of somatostatin(SST)and ANO1 decreased after the treatment(P<0.05)and were lower in the acupuncture group than in the Western medication group(P<0.05).The total effective rate was 93.0%(53/57)in the acupuncture group,higher than 76.8%(43/56)in the Western medication group(P<0.05).Conclusion Tiao Wei Tong Fu acupuncture method

关 键 词：针刺疗法 针药并用 糖尿病 胃轻瘫 糖尿病并发症 跨膜蛋白16A 

分 类 号：R246.1[医药卫生—针灸推拿学]