动态血压监测不同剂型硝苯地平在原发性高血压患者中的治疗效果  

Effect of Different Dosage Forms of Nifedipine on Ambulatory Blood Pressure Monitoring in Patients with Essential Hypertension

作　　者：张伟 ZHANG Wei(Department of General Practice,Ninghe Hospital of Ninghe District,Tianjin 301500,China)

机构地区：[1]天津市宁河区宁河医院全科,天津301500

出　　处：《医学信息》2022年第10期152-154,共3页Journal of Medical Information

摘　　要：目的观察动态血压监测仪监测不同剂型硝苯地平在原发性高血压患者中的实施效果。方法选取2018年8月-2020年8月我院收治的80例原发性高血压患者为研究对象,采用随机数字表法为对照组和观察组,各40例。对照组给予硝苯地平缓释片治疗,观察组给予硝苯地平控释片治疗,比较两组治疗前后平均血压水平、24 h内平均血压水平及不良反应发生情况。结果两组舒张压、收缩压均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组24 h平均舒张压、收缩压均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血尿酸水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%,与对照组7.50%比较,差异无统计学意义(P>0.05)。结论硝苯地平缓释片与硝苯地平控释片治疗原发性高血压均具有一定的降压作用,且临床应用安全性无明显差异,但硝苯地平控释片降压效果更优,且稳定。Objective To observe the effect of different dosage forms of nifedipine in patients with essential hypertension monitored by ambulatory blood pressure monitor.Methods A total of 80 patients with essential hypertension admitted to our hospital from August 2018 to August 2020 were selected as the research objects,which were divided into the control group and observation group by random number table method,with 40 cases in each group.The control group was treated with nifedipine sustained-release tablets,and the observation group was treated with nifedipine controlled-release tablets.The average blood pressure level before and after treatment,the average blood pressure level within 24 h and the occurrence of adverse reactions were compared between the two groups.Results The diastolic blood pressure and systolic blood pressure of the two groups were lower than those before treatment,and those in the observation group was lower than the control group,the difference was statistically significant(P<0.05).The 24 h average diastolic blood pressure and systolic blood pressure of the two groups were lower than those before treatment,and those in the observation group was lower than the control group,the difference was statistically significant(P<0.05).The levels of serum uric acid in the two groups were lower than those before treatment,and that in the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was compared 7.50%in the control group,the difference was not statistically significant(P>0.05).Conclusion Nifedipine sustained release tablets and nifedipine controlled release tablets have certain antihypertensive effect in the treatment of essential hypertension,and there is no significant difference in clinical application safety,but nifedipine controlled release tablets have better antihypertensive effect and stability.

关 键 词：原发性高血压 硝苯地平 动态血压监测仪 

分 类 号：R544.1[医药卫生—心血管疾病]