肺癌肿瘤标记物结合胸部CT检查肺结节的定性分析  

Qualitative Analysis of Lung Cancer Tumor Markers Combined with Chest CT Examination of Pulmonary Nodules

作　　者：张铁彪 刘建华[1] 马长顺 ZHANG Tie-biao;LIU Jian-hua;MA Chang-shun(Department of General Internal Medicine1,Department of Respiratory2,Department of Imaging3,Beijing Chaoyang Hospital(Huairou)of Capital Medical University,Beijing 101400,China)

机构地区：[1]首都医科大学北京朝阳医院怀柔医院综合内科1,呼吸科2,影像科3,北京101400

出　　处：《医学信息》2022年第10期171-173,共3页Journal of Medical Information

摘　　要：目的研究肺癌肿瘤标记物结合胸部CT对肺结节的定性诊断价值。方法选取我院2019年1月-2020年12月的肺结节患者153例,根据临床病理检查结果,将78例肺恶性结节设为恶性组,将75例肺良性结节设为良性组,比较两组非小细胞肺癌抗原21-1(CYFRA21-1)、鳞状细胞癌抗原(SCCA)水平及胸部CT征象,分析两种方法单一诊断及联合诊断肺结节性质的诊断效能。结果恶性组CYFRA21-1、SCCA水平高于对照组,差异有统计学意义(P<0.05);CT征象显示,良性结节边缘清楚光滑、未见分叶及毛刺征;恶性结节边缘模糊毛糙,可见分叶及毛刺征;胸部CT联合肿瘤标记物诊断肺结节性质的敏感度、特异性度、准确率、阳性预测值、阴性预测值、Kappa值均高于胸部CT、肿瘤标记物单一诊断(P<0.05)。结论肺癌肿瘤标记物CYFRA21-1、SCCA联合胸部CT有利于肺结节的定性分析。Objective To study the qualitative diagnostic value of lung cancer tumor markers combined with chest CT in detecting pulmonary nodules.Methods A total of 153 patients with pulmonary nodules in our hospital from January 2019 to December 2020 were selected.According to the results of clinical and pathological examination,78 cases of malignant pulmonary nodules were set as malignant group,and 75 cases of benign pulmonary nodules were set as benign group.The levels of CYFRA21-1,squamous cell carcinoma antigen(SCCA)and chest CT signs in the two groups were compared,and the diagnostic efficacy of single diagnosis and combined diagnosis of pulmonary nodules was analyzed.Results The levels of CYFRA21-1 and SCCA in the malignant group were higher than those in the control group,and the difference was statistically significant(P<0.05).CT signs showed that the edge of benign nodules was clear and smooth,without lobulation and burr sign;malignant nodules edge fuzzy rough,visible lobulation and spiculation;the sensitivity,specificity,accuracy,positive predictive value,negative predictive value and Kappa value of chest CT combined with tumor markers in the diagnosis of pulmonary nodules were significantly higher than those of chest CT and single diagnosis of tumor markers(P<0.05).Conclusion The lung cancer tumor markers CYFRA21-1,SCCA combined with chest CT are beneficial to the qualitative analysis of pulmonary nodules.

关 键 词：肺癌肿瘤标记物 胸部CT 肝硬化 肺结节 定性分析 

分 类 号：R563[医药卫生—呼吸系统]