白细胞介素6启动子区基因多态性与肺结核易感性的相关性  

Correlation between Gene Polymorphisms in the Interleukin 6 Promoter Region and Pulmonary Tuberculosis Susceptibility

作　　者：尚耀民[1] 胡旭 周晓蕾[2] 宋文斌 邢宝春 SHANG Yaomin;HU Xu;ZHOU Xiaolei(Department of Tuberculosis,He’nan Provincial Chest Hospital,Zhengzhou City,He’nan Province 450000;不详)

机构地区：[1]河南省胸科医院结核内科,河南省郑州市450000 [2]河南省胸科医院呼吸与危重症科,河南省郑州市450000 [3]光山县人民医院呼吸与危重症科

出　　处：《医学理论与实践》2022年第10期1628-1630,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨白细胞介素6(IL-6)启动子区-174及-572基因多态性与肺结核(PTB)易感性的相关性。方法:选取2019年6月—2021年3月我院收治的115例肺结核患者(观察组),并随机选取同期在我院体检的健康人群101例(对照组)。收集两组一般资料并采用PCR-RFLP检测两组受试者IL-6-174G/C及-572C/G位点的基因多态性,比较分析两组各位点基因型及等位基因分布频率差异。结果:两组受试者IL-6-174G/C位点GG基因型频率及G等位基因频率比较无显著差异(P<0.05),但观察组IL-6-572C/G位点CC基因型频率及C等位基因频率明显高于对照组(P>0.05);Logistic回归分析显示IL-6-572C/G位点CC基因型是肺结核患者易感性的独立危险因素。结论:IL-6基因启动子区-572C/G位点多态性可能与肺结核易感性相关,CC基因型人群发病风险相对更高。Objective:To investigate the correlation between gene polymorphism of interleukin 6(IL-6)promoter region-174 and-572 and pulmonary tuberculosis(PTB)susceptibility.Methods:A total of 115 patients(observation group)with PTB who admitted to our hospital from June 2019 to March 2021 were selected,and 101 healthy people(control group)who underwent physical examination during the same period were randomly selected.General data of the two groups were collected and PCR-RFLP was used to detect the gene polymorphism of IL-6-174 G/C and-572 C/G sites in the two groups,and the differences in genotype and allele distribution frequency of each site in the two groups were compared and analyzed.Results:There was no difference in the frequency of GG genotype and G allele at IL-6-174 G/C site between the two groups(P<0.05),but the CC genotype frequency and C allele frequency of IL-6-572 C/G site in observation group were significantly higher than those in control group(P<0.05);Logistic regression analysis showed that IL-6-572 C/G CC genotype was an independent risk factor for the susceptibility of patients with tuberculosis.Conclusion:The IL-6 gene promoter-572 C/G site polymorphism may be associated with the susceptibility of PTB,and CC genotypes have a relatively higher risk of PTB.

关 键 词：白细胞介素6 基因多态性 肺结核 基因型 

分 类 号：R521[医药卫生—内科学]