真武汤合拯阳理劳汤治疗慢性心力衰竭(肺肾两虚、水气凌心证)患者的临床疗效  

Clinical Observation of Zhenwu Decoction Combined with Zhengyang Lilao Decoction in the Treatment of Chronic Heart Failure(Deficiency of Lung and Kidney,Syndrome of Water Qi Ling Heart)

作　　者：孙晓波 白长川 黄健[1] 李晓萌 石岩[2] SUN Xiao-Bo;BAI Chang-Chuan;HUANG Jian;LI Xiao-Meng;SHI Yan(Department of Cardiology,Dalian Hospital of Traditional Chinese Medicine,Dalian 116013,China;Graduate school,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]大连市中医医院心血管科,辽宁大连116013 [2]辽宁中医药大学研究生院,沈阳110032

出　　处：《中国药物经济学》2022年第3期22-26,44,共6页China Journal of Pharmaceutical Economics

基　　金：国家重点基础研究发展计划(973计划)(2013CB532004);国家科技支撑计划(2014BAI10B04);国家中医药管理局全国名中医传承工作室建设项目(国中医药办人教函[2018]119号);辽宁省自然基金指导计划项目(2019-ZD-0889);大连市中医药相关科学研究计划项目(20Z11022)。

摘　　要：目的探讨真武汤合拯阳理劳汤治疗慢性心力衰竭(肺肾两虚、水气凌心证)患者的临床疗效。方法选取2018年1月至2020年1月就诊于大连市中医医院心血管科的慢性心力衰竭(肺肾两虚、水气凌心证)患者114例作为研究对象,根据随机数字表法分为观察组与对照组,各57例。对照组给予西医常规抗心力衰竭治疗,观察组在对照组基础上给予真武汤合拯阳理劳汤,治疗时间为2周。比较两组患者临床疗效、Lee心衰积分、N末端B型利钠肽前体(NT-proBNP)、中医证候积分、6 min步行距离及左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室收缩末期容积(LVESV)。结果观察组中医证候治疗有效率为92.98%,明显优于对照组78.94%(P<0.05);观察组心功能治疗有效率为84.21%,明显高于对照组64.91%(P<0.05)。治疗后两组Lee心衰积分、NT-proBNP、中医证候积分较治疗前降低,且观察组优于对照组,差异有统计学意义(P<0.05);治疗后两组6 min步行距离、LVEF较治疗前明显增加,且观察组明显高于对照组,差异有统计学意义(P<0.05);治疗后两组LVESD、LVESV较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05);两组患者治疗中未出现不良反应。结论真武汤合拯阳理劳汤治疗肺肾两虚、水气凌心型心力衰竭临床疗效显著,可明显提高患者心功能和运动耐量,临床安全性较高。Objective To observe the clinical efficacy of Zhenwu Decoction combined with Zhengyang Lilao Decoction in the treatment of chronic heart failure(deficiency of lung and kidney,water Qi Ling heart syndrome).Methods A total of 114 patients with chronic heart failure(deficiency of lung and kidney,syndrome of water qi ling heart)who were treated in the Department of Cardiology of Dalian Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected as the research objects,and they were divided into treatment group and control group according to the random number table method,57 cases in each.Control group was given conventional western medicine heart failure treatment,treatment group on the basis of the control group was given true Wu Shang generously YangLi fatigue soup,treatment time is 2 weeks.Clinical efficacy,Lee's heart failure score,NT-proBNP,TCM syndrome total score,6-minute walking distance,left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and left ventricular end-systolic volume(LVESV)were observed in 2 groups after treatment.Results After treatment,the total effective rate of TCM syndrome score in treatment group was 92.98%,which was significantly better than that in control group(78.94%,P<0.05).;the total effective rate of heart function in the treatment group was 84.21%,which was significantly higher than that in the control group(64.91%,P<0.05).After treatment,Lee's score of heart failure,NT-proBNP and total score of TCM syndromes in both groups were lower than before treatment,and the treatment group was better than the control group,the difference was statistically significant(P<0.05);after treatment,the 6-minute walking distance and LVEF of the 2 groups were significantly increased,and the treatment group was higher than the control group,the difference was statistically significant(P<0.05);after treatment,LVESD and LVESV in both groups were significantly lower than before treatment,and the treatment group was significantly lower than the c

关 键 词：真武汤 拯阳理劳汤 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R289.5[医药卫生—内科学]