卡格列净对2型糖尿病患者围手术期心力衰竭发生率及相关指标的影响  

Effects of Cagliquin on the Incidence of Perioperative Heart Failure and Related Indexes in Patients with Type 2 Diabetes

作　　者：纪焕春[1] 彭威[1] 杨龙[1] 曲静仙 张金芳[1] 姚福梅[1] JI Huan-Chun;PENG Wei;YANG Long;QU Jing-Xian;ZHANG Jin-Fang;YAO Fu-Mei(Department of Cardiology,Dalian Second People's Hospital(Dalian Integrated Traditional Chinese and Western Medicine Hospital),Dalian 116019,China)

机构地区：[1]大连市第二人民医院(大连市中西医结合医院)心内科,辽宁大连116019

出　　处：《中国药物经济学》2022年第3期35-39,共5页China Journal of Pharmaceutical Economics

基　　金：大连市医学科学研究计划项目(2020.023x)。

摘　　要：目的探讨卡格列净对2型糖尿病患者围手术期心力衰竭发生率及相关指标的影响。方法选取2017年10月至2020年6月大连市第二人民医院收治的围手术期2型糖尿病患者160例作为研究对象,按照治疗方案不同分为对照组(77例)与观察组(83例)。对照组给予二甲双胍联合胰岛素治疗,观察组给予卡格列净联合胰岛素治疗,比较两组心力衰竭发生率、心功能相关指标[心率、N末端脑钠肽前体(NT-proBNP)、6 min步行距离(6MWD)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]、糖代谢相关指标[空腹血糖(FBG)、餐后2 h血糖(2hPBG)、胰岛素抵抗指数(HOMA-IR)]、炎症介质[肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)]及不良反应。结果随访结果显示,观察组、对照组心力衰竭发生率分别为2.41%、20.78%,差异有统计学意义(P<0.05);治疗后,观察组心率、NT-proBNP、LVEDD、LVESD、FBG、2hPBG、HOMA-IR、TNF-α、IL-1、IL-6水平显著低于对照组,6MWD、LVEF水平显著高于对照组,差异有统计学意义(P<0.05);观察组、对照组不良反应发生率分别为3.61%、23.38%,差异有统计学意义(P<0.05)。结论卡格列净能够有效降低2型糖尿病患者围手术期心力衰竭发生率,有助于改善心功能、糖代谢相关指标,疗效显著,同时具有较高的安全性。Objective To explore the effects of cagliquin on the incidence of perioperative heart failure and related indexes in patients with type 2 diabetes mellitus.Methods A total of 160 patients with type 2 diabetes in perioperative period admitted to Dalian Second People's Hospital from October 2017 to June 2020 were selected as the research objects and were divided into a control group and an observation group according to different treatment regimens.The control group(n=77)was treated with metformin combined with insulin,and study group(n=83)was treated with caglijin combined with insulin.The incidence of heart failure,cardiac function related indicators[heart rate,N-terminal pro-brain natriuretic peptide(NT-proBNP),6 minute walking distance(6MWD)left ventricular end-diastolic dimension(LVEDD),left ventricular end-stolic diameter(LVESD),and left ventricular ejection fraction(LVEF)],glucose metabolism related indicators[fiber Bragg Grating(FBG),postprandial blood glucose(PBG),homeostatic model assessment of insulin resistance(HOMA-IR)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6)]and adverse reactions were compared between the 2 groups.Results According to the results of follow-up,the incidence of heart failure in the study group and the control group was 2.41%and 20.78%,respectively,and there was statistical significance between groups(P<0.05).After treatment,heart rate,NT-proBNP,LVEDD,LVESD,FBG,2hPBG,HOMA-IR,TNF-α,IL-1 and IL-6 levels in the study group were significantly lower than those in the control group,and 6MWD and LVEF levels were significantly higher than those in the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the study group and the control group was 3.61%and 23.38%,respectively,and the comparison between groups showed statistical significance(P<0.05).Conclusion Cagliquin can effectively reduce the incidence of perioperative heart failure in patients with type 2 diabetes,help to improve cardiac function,glucose

关 键 词：卡格列净 2型糖尿病 围手术期 心力衰竭 安全性 

分 类 号：R587.2[医药卫生—内分泌] R977.1[医药卫生—内科学]