河南省郑州地区居民气道高反应性发病情况调查与分析  

Investigation and analysis on the incidence of airway hyperresponsiveness among rural residents in Zhengzhou city of Henan province

作　　者：赵桂华[1] 张娜[1] 徐金义[1] 张静[1] 王云朋 王晓娜 郭现平 赵丽敏[2] ZHAO Guihua;ZHANG Na;XU Jinyi;ZHANG Jing;WANG Yunpeng;WANG Xiaona;GUO Xianping;ZHAO Limin(Department of Cardiology function,Henan Provincial People's Hospital,Zhengzhou 450003,Henan Province,China;Department of respiratory and critical care medicine,Henan Provincial People's Hospital,Zhengzhou 450003,Henan Province,China)

机构地区：[1]河南省人民医院心肺功能科,河南郑州450003 [2]河南省人民医院呼吸科,河南郑州450003

出　　处：《新乡医学院学报》2022年第4期346-349,共4页Journal of Xinxiang Medical University

基　　金：河南省医学科技攻关计划省部共建项目(编号:SB201901092);河南省医学科技攻关计划项目(编号:LHGJ20200055)。

摘　　要：目的调查分析河南省气道高反应性(AHR)发病情况。方法选择2016年1月至2019年12月于郑州大学附属人民医院(河南省人民医院)就诊和体检的31602人为受试者。采用肺功能仪检测所有受试者的肺通气功能,并根据肺通气功能不同将受试者分为正常组(肺通气功能正常)、小气道功能减低组(小气道功能减低)、轻度阻塞性组(轻度阻塞性肺通气功能障碍)、轻度限制性组(轻度限制性肺通气功能障碍)。采用支气管激发试验检测所有受试者AHR情况。结果31602例受试者中,AHR总检出率为29.48%(9318/31602),男性AHR检出率为28.42%(4173/14685),女性AHR检出率为30.41%(5145/16917),男性与女性AHR检出率比较差异无统计学意义(χ^(2)=1.618,P>0.05)。21~29岁、30~39岁,40~49岁、50~59岁女性的AHR检出率均显著高于男性相应年龄范围(P<0.05);6~20岁、60~69岁、≥70岁男性与女性的AHR检出率比较差异无统计学意义(P>0.05);6~20岁男性、女性就诊人群的AHR检出率均显著高于其他年龄范围(P<0.05)。正常组受试者的AHR检出率显著低于小气道功能减低组、轻度阻塞性组、轻度限制性组(χ^(2)=4.831、2.074、6.118,P<0.05);轻度阻塞性组受试者的AHR检出率显著高于小气道功能减低组和轻度限制性组(χ^(2)=4.006、3.072,P<0.05);小气道功能减低组和轻度限制性组受试者的AHR检出率比较差异无统计学意义(χ^(2)=0.893,P>0.05)。AHR与性别无显著相关性(r=0.039,P>0.05),与基础肺通气功能显著相关性(r=5.137,P<0.05)。结论AHR高发于6~20岁人群,且AHR与性别无显著相关性,与基础肺通气功能有显著相关性。Objective To investigate and analyze the incidence of airway hyperresponsiveness(AHR)among rural residents in Zhengzhou city of Henan province.Methods A total of 31602 people who visited and examined the Henan Provincial People′s Hospital from January 2016 to December 2019 were selected as observation objects.The pulmonary ventilation function of all subjects was detected by pulmonary function test,and the subjects were divided intonormal group(normal pulmonary ventilation function),small airway function reduction group(reduced small airway function),mild obstructive group(mild obstructive pulmonary ventilation dysfunction),mild restrictive group(mild restrictive pulmonary ventilation dysfunction)according to different pulmonary ventilation functions.The AHR in all subjects was detected by Bronchial provocation test.Results Among the 31602 observation subjects,the total detection rate of AHR was 29.48%(9318/31602),the detection rate of AHR in male was 28.42%(4173/14685),and the detection rate of AHR in female was 30.41%(5145/16917).There was no significant difference in the rate of AHR between males and females(χ^(2)=1.618,P>0.05).The AHR detection rate in women aged 21-29,30-39,40-49,and 50-59 were significantly higher than that in men in the corresponding age range(P<0.05);there was no significant difference in the detection rate of AHR between males and females aged 6-20,60-69 and≥70(P>0.05);the detection rates of AHR in males and females aged 6-20 were significantly higher than those in other age ranges(P<0.05).The AHR detection rate of the observation objects in the normal group was significantly lower than that in the small airway function reduction group,the mildly obstructive group,the mild restrictive group(χ^(2)=4.831,2.074,6.118,P<0.05);The AHR detection rate of the subjects in the mild obstructive group was significantly higher than that in the small airway function reduction group and the mild restrictive group(χ^(2)=4.006,3.072;P<0.05);there was no significant difference in the AHR detection

关 键 词：肺通气功能 支气管激发试验 气道高反应 

分 类 号：R56[医药卫生—呼吸系统]