CD14基因-159C/T多态性与变应性鼻炎易感性关系的meta分析  

Association between CD14 gene-159C/T polymorphisms and the susceptibility of allergic rhinitis:a metaanalysis

作　　者：冯会杰[1] 杜翠萍[1] 白素娟[1] FENG Huijie;DU Cuiping;BAI Sujuan(Department of Otorhinolaryngology,Shanghai Putuo District People’s Hospital,Shanghai 200060,China)

机构地区：[1]上海市普陀区人民医院耳鼻咽喉科,上海200060

出　　处：《中国眼耳鼻喉科杂志》2022年第3期236-241,共6页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的探讨CD14基因-159C/T多态性与变应性鼻炎(AR)发病风险的相关性。方法检索中国学术期刊文献数据库和PubMed,Embase等查找有关CD14基因-159C/T多态性与AR易感性关系的病例对照研究,采用Stata l5.0统计学软件进行meta分析。结果最终共纳入9篇文献,均为病例对照研究,其中病例组1195例、对照组1124例。meta分析总体结果:T vs C等位基因和4种基因模型在病例组和对照组间的差异无统计学意义。此外,按对照组来源和单核苷酸多态性(SNP检测法)进行亚组分析:T vs C等位基因和各基因模型在病例组和对照组间的差异无统计学意义。当按种族进行亚组分析时发现,在非洲人群中,等位基因T vs C(OR=2.05,95%CI:1.47~2.86;P<0.05)、显性模型TT+CT vs CC(OR=2.00,95%CI:1.24~3.22;P=0.004)、隐性模型TT vs CC+CT(OR=4.04,95%CI:2.02~8.09;P<0.05)、TT vs CC(OR=5.02,95%CI:2.37~10.63;P<0.05)在病例组和对照组间的差异有统计学意义,而CT vs CC(OR=1.48,95%CI:0.89~2.45;P=0.129)差异无统计学意义。在亚洲人群中,病例组和对照组间的差异均无统计学意义。结论亚洲人群中,CD14基因-159C/T多态性与AR易感性无明显相关性;非洲人群中埃及儿童CD14基因-159位点的T等位基因与特应性哮喘和AR有关,TT基因与烟草烟雾暴露儿童免疫球蛋白E(IgE)水平升高有关。Objective To investigate the association between CD14 gene-159C/T polymorphism and the allergic rhinitis(AR).Methods Literatures on CD14 gene-159C/T polymorphism and AR susceptibility were collected by searching PubMed,EMBase,Wanfang and other databases.Meta analysis was conducted by using Stata l5.0 software.Results Nine studies were collected,which involved 1195 cases and 1124 controls.In the overall populations,the results of meta-analysis showed that no statistically significant differences were found between cases and controls in allele and genetic models.In the subgroup analysis by ethnicity,in Africa populations,T vs C(OR=2.05,95%CI:1.47-2.86;P<0.05),dominant model TT+CT vs CC(OR=2.00,95%CI:1.24-3.22;P=0.004),recessive model TT vs CC+CT(OR=4.04,95%CI:2.02-8.09;P<0.05),TT vs CC(OR=5.02,95%CI:2.37-10.63;P<0.05)were all statistically different between the case group and the control group.Conclusions The CD14 gene-159C/T polymorphism is not associated with the risk of AR in Asian populations,while probably related to liability of AR in Africa populations.

关 键 词：变应性鼻炎 CD14基因-159C/T 基因多态性 META分析 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]