T_(2) mapping技术监测缺血再灌注后心肌水肿动态改变:动物实验研究  

Monitoring dynamic changes of myocardial edema after myocardial ischemia/reperfusion by T_(2)mapping:an animal experimental study

作　　者：许可 杨梦犀 谢林均 徐蓉 张露 郭应坤[1] 傅航 陈林 许华燕 XU Ke;YANG Mengxi;XIE Linjun;XU Rong;ZHANG Lu;GUO Yingkun;FU Hang;CHEN Lin;XU Huayan(Department of Radiology,Key Laboratory of Obstetric&Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院放射科出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041

出　　处：《实用放射学杂志》2022年第3期487-491,共5页Journal of Practical Radiology

基　　金：国家自然科学面上基金项目(81971586,81771887);国家自然科学青年基金项目(81901712);四川省科技厅重点研发项目(2020YFS0050,21ZDF1967);中华医学会心血管病分会(CSC)临床研究专项基金项目(HFCSC2019B01).

摘　　要：目的探究T_(2) mapping技术对心肌缺血/再灌注(I/R)后心肌水肿长期动态改变的监测作用.方法对7只恒河猴进行I/R手术.所有动物于术前、术后7 d、30 d及90 d接受一系列心脏磁共振(CMR)检查.扫描序列包括T_(2) mapping、电影及钆对比剂延迟强化序列.将心肌分为梗死区、过渡区和远端心肌,测量不同区域在不同时间点的T_(2)弛豫时间.结果I/R后7 d,梗死区和过渡区T_(2)弛豫时间高于远端心肌(P<0.05);I/R后90 d,过渡区心肌与远端心肌的T_(2)弛豫时间无统计学差异,而梗死区心肌T_(2)弛豫时间仍显著高于远端心肌(P<0.05).I/R后7~90 d,远端节段各时间点的T_(2)弛豫时间无统计学差异(P=0.207).而梗死区和过渡区心肌T_(2)弛豫时间持续降低.且I/R后90 d过渡心肌T_(2)弛豫时间已基本恢复至术前正常水平,而梗死区心肌仍高于造模前正常心肌(P<0.05).结论T_(2) mapping技术可定量评估I/R后心肌水肿的严重程度并监测其动态进程.I/R后7~90 d梗死和过渡节段心肌水肿均逐渐降低,但梗死区心肌水肿在I/R后90 d时仍持续存在.Objective To explore monitoring value of T_(2) mapping for long-term dynamic changes of myocardial edema after myocardial ischemia/reperfusion(I/R).Methods I/R operation was performed on 7 rhesus monkeys.All animals underwent a series of cardiac magnetic resonance(CMR)before operation and at 7 days,30 days and 90 days after operation.Scanning sequences included T_(2) mapping,cine and late gadolinium enhancement.The myocardium was divided into infarcted segments,transition segments and remote segments.The T_(2) relaxation time of different segments at different time points was measured.Results The T_(2) relaxation time of infarcted and transition segments were significantly higher than remote segments at 7 days after I/R(P<0.05).At 90 days after I/R,there was no statistical difference of T_(2) relaxation time between transition segments and remote segments,but T_(2) relaxation time of infarcted segments was still significantly higher than remote segments(P<0.05).From 7 days to 90 days after I/R,no statistical difference was found in T_(2) relaxation time of remote segments at different time points(P=0.207).However,T_(2) relaxation time of infarcted and transition segments decreased persistently.At 90 days after I/R,T_(2) relaxation time of transition segments basically returned to the normal level of pre-operation,while the T_(2) relaxation time of infarcted segments was still higher than that of the normal myocardium before modeling(P<0.05).Conclusion T_(2) mapping can quantitatively assess severity of myocardial edema and monitor dynamic progression.From 7 days to 90 days after I/R,myocardial edema of infarcted and transition segments reduced continuously,but the edema of infarcted segments is still subsistent at 90 days after I/R.

关 键 词：心肌梗死 T_(2)mapping 心脏磁共振 水肿 

分 类 号：R542.22[医药卫生—心血管疾病] R445.2[医药卫生—内科学] R442.5[医药卫生—临床医学]