新生儿坏死性小肠结肠炎研究新进展  

Neonatal necrotizing enterocolitis:advances and challenges

作　　者：汪健[1] Wang Jiang(Department of Urology,Children's Hospital,Suzhou 215003,China)

机构地区：[1]苏州大学附属儿童医院新生儿外科,苏州215003

出　　处：《临床小儿外科杂志》2022年第4期301-305,共5页Journal of Clinical Pediatric Surgery

基　　金：国家自然科学基金(81871594)。

摘　　要：坏死性小肠结肠炎(necrotizing enterocolitis,NEC)是新生儿最具破坏性的肠道炎症性疾病之一,目前其发病率及病死率居高不下。本文总结近年来关于NEC诊治方面的研究进展,提出单一或多组学研究可能有助于NEC的预测与早期诊断,肠道超声在提高NEC的诊断准确性方面显示出新希望;强调要重视NEC小肠造瘘术后的营养支持;羊水干细胞(amniotic fluid-derived stem cells,AFSCs)治疗有望成为预防新生儿NEC的新策略。Necrotizing enterocolitis(NEC)is one of the most destructive inflammatory bowel diseases in neonates.Its incidence and mortality rate have remained high.This review summarized the latest researches of NEC diagnosis and treatment.Single or multi-omic approaches may aid in its prediction or early diagnosis.Bowel ultrasound(BUS)proves promising in improving its diagnostic accuracy.Due attention should be devoted to nutritional supports after enterostomy.Amniotic fluid stem cells(AFSCs)are expected to be a new preventive strategy for neonatal NEC.

关 键 词：小肠结肠炎 坏死性/诊断 小肠结肠炎 坏死性/外科学 小肠结肠炎 坏死性/膳食疗法 代谢组学 超声检查 羊水干细胞 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]