血清免疫球蛋白(Ig)A、IgM、IgG结合肝功能指标检验在肝衰竭诊断及预后判断中的运用研究  

Application of Serum Immunoglobulin(Ig)A,IgM,IgG Combined with Liver Function Index Test in the Diagnosis and Prognosis of Liver Failure

作　　者：严丽花 梁雪琼[1] 刘翠娴[1] 罗莉芸[1] YAN Lihua;LIANG Xueqiong;LIU Cuixian;LUO Liyun(Department of Laboratory Medicine,Gaoming District People's Hospital,Foshan,Guangdong Province,528500 China)

机构地区：[1]广东省佛山市高明区人民医院检验科,广东佛山528500

出　　处：《系统医学》2022年第3期24-27,共4页Systems Medicine

摘　　要：目的研究血清免疫球蛋白(Ig)A、IgM、IgG结合肝功能指标检验在肝衰竭诊断及预后判断中的运用价值。方法选择2020年1月—2021年1月该院诊断且确诊的肝衰竭患者56例作为该次研究组,选择同期在该院体检的健康人群50名作为健康对照组,均给予两组IgA、IgM、IgG结合肝功能指标检验,对比分析两组检验的结果。结果研究组IgA、IgM、IgG水平分别为(5.41±1.29)、(5.79±1.21)、(18.94±2.37)g/L,健康对照组IgA、IgM、IgG水平分别为(1.49±0.32)、(1.38±0.17)、(10.39±2.04)g/L;相较于健康对照组,研究组患者IgA、IgM、IgG水平更高,差异有统计学意义(t=20.910、25.534、19.788,P<0.05)。研究组GGT、AST、ALT水平分别为(79.56±3.46)、(118.46±15.32)、(206.18±15.34)U/L,健康对照组GGT、AST、ALT水平分别为(13.26±1.42)、(16.87±2.41)、(26.98±1.26)U/L,研究组较健康对照组更高,差异有统计学意义(t=126.281、173.443、82.313,P<0.05)。IgA、IgM、IgG和肝功能指标GGT、AST、ALT均是威胁肝衰竭患者预后转归的危险因素(P<0.05);联合检测IgA、IgM、IgG、GGT、AST、ALT所达到的AUC值最大,差异有统计学意义(P<0.05)。结论IgA、IgM、IgG结合肝功能指标能够进一步提升肝衰竭检出率,进而为临床改善预后提供可参考的依据,值得推广。Objective To study the application value of serum immunoglobulin(Ig)A,IgM,IgG combined with liver function index tests in the diagnosis and prognosis of liver failure.Methods 56 patients with liver failure diagnosed and confirmed in the hospital from January 2020 to January 2021 were selected as the study group.50 healthy people who received physical examination in the hospital during the same period were selected as the healthy control group.Both groups were given IgA,IgM,and IgG combined with liver function index tests.Compared and analyzed the results of the two sets of tests.Results The levels of IgA,IgM,and IgG in the study group were(5.41±1.29)g/L,(5.79±1.21)g/L,and(18.94±2.37)g/L,respectively.The levels of IgA,IgM,and IgG in the healthy control group was(1.49±0.32)g/L,(1.38±0.17)g/L,(10.39±2.04)g/L,respectively.Compared with the healthy control group,patients in the study group were higher levels of IgA,IgM,and IgG,the difference was statistically significant(t=20.910,25.534,19.788,P<0.05).The levels of GGT,AST,and ALT in the study group were(79.56±3.46)U/L,(118.46±15.32)U/L,and(206.18±15.34)U/L,respectively.The healthy control group was(13.26±1.42)U/L,(16.87±2.41)U/L,(26.98±1.26)U/L,respectively.The study group was higher than the healthy control group,the difference was statistically significant(t=126.281,173.443,82.313,P<0.05).IgA,IgM,IgG and liver function indicators GGT,AST,ALT were all risk factors that threaten the prognosis of patients with liver failure(P<0.05).Combined detection of IgA,IgM,IgG,GGT,AST,ALT reached the highest AUC value,the difference was statistically significant(P<0.05).Conclusion IgA,IgM,IgG combined with liver function indicators can further increase the detection rate of liver failure,and provide a reference for clinical improvement of prognosis,which is worthy of promotion.

关 键 词：血清免疫球蛋白(Ig)A IGM IGG 肝功能 肝衰竭 诊断 预后 

分 类 号：R446[医药卫生—诊断学]