丙泊酚联合依托咪酯用药在冠心病患者行非心脏手术全麻诱导中的应用  

Application of Propofol Combined with Etomidate in Induction of General Anesthesia in Patients with Coronary Heart Disease Undergoing Non-Cardiac Surgery

作　　者：刁世琪 刘宗明[1] 张奇[1] 王雷[2] DIAO Shiqi;LIU Zongming;ZHANG Qi;WANG Lei(Department of Anesthesiology,Jilin Provincial Tumor Hospital,Changchun,Jilin Province,130000 China;Department of Nuclear Medicine,Jilin Provincial Tumor Hospital,Changchun,Jilin Province,130000 China)

机构地区：[1]吉林省肿瘤医院麻醉科,吉林长春130000 [2]吉林省肿瘤医院核医学科,吉林长春130000

出　　处：《系统医学》2022年第3期28-31,共4页Systems Medicine

基　　金：吉林省卫生与健康青年科技骨干培养计划项目(2020Q037)。

摘　　要：目的讨论丙泊酚联合依托咪酯用药在冠心病患者行非心脏手术全麻诱导中的应用效果。方法随机选取2019年1月—2020年1月在该院进行非心脏病手术治疗的86例冠心病患者作为研究对象,按照患者的入院时间将其分为研究组和对照组,每组43例。选择采用丙泊酚麻醉的患者设定为对照组,选择采用丙泊酚联合依托咪酯的患者作为研究组,对两组患者的麻醉效果进行对比和分析。结果两组患者不良反应和血管活性药物使用情况对比,对照组患者发生心动过缓8例,发生率为18.6%,研究组患者发生心动过缓0例,发生率为0.0%,两组比较,差异有统计学意义(χ^(2)=6.753,P=0.009);对照组患者发生心动过速7例,发生率为16.2%,研究组患者发生心动过速0例,发生率为0.0%,研究组明显优于对照组,差异有统计学意义(χ^(2)=5.598,P=0.017)。对照组SBP(102.5±8.2)mmHg,DBP(56.8±6.5)mmHg,与研究组SBP(98.3±5.3)mmHg,DBP(63.5±3.8)mmHg对比,差异有统计学意义(t=2.820、5.835,P<0.05)。结论丙泊酚联合依托咪酯用药在冠心病患者行非心脏手术全麻诱导中可较好地维持血液动力学稳定,临床应用效果较好,值得应用和推广。Objective To discuss the effect of propofol combined with etomidate in the induction of general anesthesia in patients with coronary heart disease undergoing non-cardiac surgery.Methods 86 patients with coronary heart disease who underwent non-cardiac surgery in the hospital from January 2019 to January 2020 were randomly selected as the subjects.The patients were divided into study group and control group according to their admission time,with 43 cases in each group.The patients who were treated with propofol were set as the control group,and the patients who were anesthesia with propofol and etomidate were selected as the study group,and the anesthesia effects of the two groups of patients were compared and analyzed.Results In the comparison of adverse reactions and the use of vasoactive drugs between the two groups,8 patients in the control group had bradycardia,the incidence rate was 18.6%,and 0 patients in the study group had bradycardia,the incidence rate was 0.0%,there was statistically significant difference between the two groups(χ^(2)=6.753,P=0.009).There were 7 cases of tachycardia in the control group,the incidence rate was 16.2%,and 0 cases of tachycardia in the study group,the incidence rate was 0.0%,the study group was significantly better than the control group,and the difference was statistically significant(χ^(2)=5.598,P=0.017).SBP(102.5±8.2)mmHg and DBP(56.8±6.5)mmHg in the control group were significantly differ ent from SBP(98.3±5.3)mmHg and DBP(63.5±3.8)mmHg in the study group,the difference was statistically significant(t=2.820,5.835,P<0.05).Conclusion Propofol combined with etomidate can better maintain hemodynamic stability during general anesthesia induction of non-cardiac surgery in patients with coronary heart disease.The clinical application effect is good,and it is worthy of application and promotion.

关 键 词：丙泊酚 依托咪酯 冠心病 非心脏手术 麻醉 

分 类 号：R4[医药卫生—临床医学]