右美托咪定与依托咪酯对患者胃癌全麻醉根治术的麻醉效果和对术后疼痛与感染的影响分析  

Analysis of the Anesthetic Effect of Dexmedetomidine and Etomidate on Patients Undergoing Radical Resection of Gastric Cancer with General Anesthesia and Their Influence on Postoperative Pain and Infection

作　　者：王倩[1] WANG Qian(Department of Anesthesiology,Shanxian Central Hospital,Shanxian,Shandong Province,274300 China)

机构地区：[1]单县中心医院麻醉科,山东单县274300

出　　处：《系统医学》2022年第3期84-87,共4页Systems Medicine

摘　　要：目的研究右美托咪定与依托咪酯在胃癌全麻醉根治术的麻醉效果以及对患者术后疼痛与感染的影响。方法选择该院2019年8月—2021年2月收治的胃癌患者78例作为该次研究对象,以随机数字表法对患者分组,研究组与对照组各39例,对照组实施依托咪酯麻醉,研究组联合右美托咪定麻醉,观察两组感染情况、疼痛评分和血流动力学指标、临床恢复时间以及麻醉前、术后6、12、24 h认知功能评分、不良反应发生情况。结果两组麻醉前疼痛评分差异无统计学意义(t=0.141,P>0.05);麻醉后研究组疼痛评分(2.08±0.41)分低于对照组(3.52±0.84)分,差异有统计学意义(t=9.621,P<0.001);麻醉前,两组收缩压与舒张压差异无统计学意义(P>0.05);研究组用药时和拔管时心率高于对照组,差异有统计学意义(t=11.253、8.827,P<0.05),两组麻醉前认知功能评分差异无统计学意义(P>0.05),研究组术后6、12、24 h认知功能评分均高于对照组,差异有统计学意义(t=17.904、16.076、26.876,P<0.001);研究组拔管时间短于对照组,定向力恢复时间快于对照组,差异有统计学意义(t=4.156、8.232,P<0.05);研究组不良反应发生率为7.69%,显著低于对照组30.77%,差异有统计学意义(χ^(2)=6.685,P<0.05);研究组不良反应发生率5.13%,低于对照组23.08%,差异有统计学意义(χ^(2)=5.186,P<0.05)。结论右美托咪定与依托咪酯联合麻醉应用在胃癌全麻根治术中的效果显著,可降低疼痛,维持血流动力学稳定,安全性高,值得临床进一步应用探讨。Objective To study the anesthetic effects of dexmedetomidine and etomidate in radical surgery of gastric cancer with total anesthesia and their effects on postoperative pain and infection.Methods 78 patients with gastric cancer admitted in the hospital from August 2019 to February 2021 were selected as the research object.The patients were divided into two groups by random number table,with 39 cases in each of the study group and the control group.The control group was anesthetized with etomidate,and the study group was anesthetized with dexmedetomidine.Observed the two groups of infection,pain score and hemodynamic indicators,clinical recovery time,cognitive function scores before anesthesia,6 h,12 h,24 h after surgery,and the occurrence of adverse reactions.Results There was no statistically significant difference in pain scores between the two groups before anesthesia(t=0.141,P>0.05).The pain score after anesthesia in the study group(2.08±0.41)points was lower than that in the control group(3.52±0.84)points,and the difference was statistically significant(t=9.621,P<0.001).There was no statistically significant difference in systolic and diastolic blood pressure between the two groups before anesthesia(P>0.05).The heart rate of the study group was higher than that of the control group at the time of medication and extubation,and the difference was statistically significant(t=11.253,8.827,P<0.05),there was no statistical difference in the cognitive function scores of the two groups before anesthesia(P>0.05).The cognitive function scores of the study group at 6 h,12 h and 24 h after surgery were higher than those of the control group,and the difference was statistically significant(t=17.904,16.076,26.876,P<0.05).The extubation time of the study group was shorter than that of the control group,and the recovery time of orientation was faster than that of the control group.the difference was statistically significant(t=4.156,8.232,P<0.05).The incidence of adverse reactions in the study group was 7.69%,which was si

关 键 词：右美托咪定 依托咪酯 胃癌 疼痛 血流动力学 

分 类 号：R614.2[医药卫生—麻醉学] R735.2[医药卫生—外科学]