匹多莫德对尖锐湿疣T淋细胞亚群的影响及对复发的预防研究  

Study on the Effect of Pidotimod on T Lymphocyte Subsets of Condyloma Acuminatum and the Prevention of Recurrence

作　　者：余璐 YU Lu(Department of Dermatology,First People's Hospital of Xianning,Xianning,Hubei Province,437000 China)

机构地区：[1]湖北省咸宁市第一人民医院皮肤科,湖北咸宁437000

出　　处：《系统医学》2022年第3期179-182,共4页Systems Medicine

摘　　要：目的探讨匹多莫德治疗尖锐湿疣T淋细胞亚群的影响及对复发的预防效果。方法选取2019年3月—2020年2月该院收治的114例尖锐湿疣患者为研究对象,采用随机数表法分为观察组和对照组,各57例。对照组给予CO_(2)激光治疗,观察组在对照组基础上联合匹多莫德治疗。治疗3个月后,比较两组T淋细胞亚群各项指标变化、不良反应发生率、临床治愈率及复发率。结果治疗后,观察组患者T淋细胞亚群CD3^(+)(63.15±7.33)%、CD4^(+)(41.62±5.22)%、CD4^(+)/CD8^(+)(1.62±0.33)显著高于对照组的(60.71±4.34)%、(37.07±2.99)%、(1.25±0.19),差异有统计学意义(t=2.162、5.710、7.335,P<0.05);治疗后,观察组患者T淋细胞亚群CD8^(+)(26.74±4.27)%显著低于对照组(30.69±5.84)%,差异有统计学意义(t=4.122,P<0.05);治疗后,观察组不良反应发生率10.53%明显低于对照组的24.56%,差异有统计学意义(χ^(2)=3.880,P<0.05);观察组临床治愈率85.96%高于对照组的70.18%,观察组复发率14.04%明显低于对照组的29.82%,差异有统计学意义(χ^(2)=4.150,P<0.05)。结论匹多莫德对尖锐湿疣患者的T淋细胞亚群异常起调节作用,减少不良反应发生,降低复发风险。Objective To investigate the effect of pidotimod on T lymphocyte subsets of condyloma acuminatum and its preventive effect on recurrence.Methods A total of 114 patients with condyloma acuminata who were admitted to the hospital from March 2019 to February 2020 were selected as the research objects.The random number table was used to divide them into observation group and control group with 57 cases each.The control group was given CO_(2)laser treatment,and the observation group was treated with pidotimod on the basis of the control group.After 3 months of treatment,the changes in various indicators of T lymphocyte subsets,adverse reactions,clinical cure rate and recurrence rates between the two groups were compared.Results After treatment,the T lymphocyte subsets CD3^(+)(63.15±7.33)%,CD4^(+)(41.62±5.22)%,CD4^(+)/CD8^(+)(1.62±0.33)of the observation group were significantly higher than those of the control group(60.71±4.34)%,(37.07±2.99)%,(1.25±0.19),the difference was statistically significant(t=2.162,5.710,7.335,P<0.05);after treatment,the observation group's T lymphocyte subset CD8^(+)(26.74±4.27)%significantly lower than the control group(30.69±5.84)%,the difference was statistically significant(t=4.122,P<0.05);after treatment,the 10.53%incidence of adverse reactions in the observation group was significantly lower than the control group's 24.56%,the difference was statistically significant(χ^(2)=3.880,P<0.05);the clinical cure rate of the observation group was 85.96%higher than that of the control group 70.18%,and the recurrence rate of the observation group was 14.04%significantly lower than that of the control group 29.82%,the difference was statistically significant(χ^(2)=4.150,P<0.05).Conclusion Pidotimod can regulate the abnormalities of T lymphocyte subsets in patients with condyloma acuminatum,reduce the occurrence of adverse reactions,and reduce the risk of recurrence.

关 键 词：匹多莫德 尖锐湿疣 T淋细胞亚群 影响 复发率 

分 类 号：R322.99[医药卫生—人体解剖和组织胚胎学]