不同性别人群脂质蓄积指数与非酒精性脂肪性肝病的关联性研究  

Gender-specific Contribution of Lipid Accumulation Product for the Identification of Nonalcoholic Fatty Liver Disease

作　　者：刘奕婷[1] 王巍[1] Liu Yiting;Wang Wei(Department of Physical Examination Center,The First Affiliated Hospital,China Medical University(110001),Shenyang)

机构地区：[1]中国医科大学附属第一医院健康体检中心,110001

出　　处：《中国卫生统计》2022年第2期210-214,共5页Chinese Journal of Health Statistics

基　　金：辽宁省自然科学基金博士启动项目(2021-BS-097)。

摘　　要：目的 探讨不同性别人群中脂质蓄积指数(lipid accumulation product, LAP)与非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)之间的关系。方法 共纳入39942例参加健康体检且符合纳入标准的受检者作为研究对象。分别在男性和女性中,应用多因素logistic回归和受试者工作特征曲线(ROC)分析LAP与NAFLD检出情况之间的关联及LAP对NAFLD筛查的临床诊断价值。结果 男性和女性中NAFLD的检出率随着LAP值的升高而逐渐递增;多因素logistic回归分析结果显示,在校正混杂因素的影响后,LAP与男性和女性NAFLD的患病风险均呈正相关;在女性中,LAP第二、三、四分位数组与第一分位数组相比,NAFLD患病风险的OR值(95%CI)分别为2.816(2.178~3.640),5.469(4.219~7.090)和8.467(6.351~11.288),男性中对应的OR值(95%CI)分别为5.868(4.965~6.936),22.299(17.892~27.791)和80.590(61.152~106.206)。ROC分析结果显示,在女性中,LAP诊断NAFLD的阈值为20,曲线下面积为0.860,其灵敏度和特异度分别为80.45%和75.99%;在男性中,LAP诊断NAFLD的阈值为26.4,曲线下面积为0.819,其灵敏度和特异度分别为72.76%和75.45%。结论 LAP作为一项方便简单的生物学合成指标,与NAFLD的患病密切相关,且LAP对NAFLD具有较高的诊断价值。Objective To investigate the relationship between lipid accumulation product(LAP)and nonalcoholic fatty liver disease(NAFLD) in different genders.Methods A total of 39942 subjects who participated in health checkup and met the criterions were included.Multivariate logistic regression and receiver operating characteristic curve(ROC) were used to evaluate the relationship between LAP and NAFLD and the clinical diagnostic value of LAP in men and women, respectively.Results The prevalence of NAFLD in men and women increased with the levels of LAP.The results of multivariate logistic regression analysis showed that after adjusting the influence of potential factors, LAP was positively correlated with the risk of NAFLD in both genders.In women, the OR(95%CI) of patients with NAFLD in Q2,Q3,and Q4 of LAP were 2.816(2.178~3.640),5.469(4.219~7.090) and 8.467(6.351~11.288),while the corresponding OR(95%CI) in men were 5.868(4.965~6.936),22.299(17.892~27.791) and 80.590(61.152~106.206),respectively.The results of ROC analysis showed that in women, the threshold of LAP in diagnosing NAFLD was 20,the area under the curve was 0.860,and the sensitivity and specificity were 80.45% and 75.99%.In men, the threshold of LAP was 26.4,the area under the curve was 0.819,and the sensitivity and specificity were 72.76% and 75.45%.Conclusion As a convenient and simple index, LAP is closely related to NAFLD and useful for the identification of NAFLD.

关 键 词：非酒精性脂肪性肝病 脂质蓄积指数 健康体检 

分 类 号：R115[医药卫生—公共卫生与预防医学]