天然生物质材料的制备、性质与应用(Ⅴ)——生物相容性良好的功能蛋白质材料:胶原蛋白  

Preparation, properties and applications of natural biomass materials (Ⅴ) Functional protein material with excellent biocompatibility:collagen peptide

作　　者：樊建茹 亓玺 郝旸 王长运 徐桂云[2] 范金石 Jianru Fan;Xi Qi;Yang Hao;Changyun Wang;Guiyun Xu;Jinshi Fan(College of Marine Science and Bioengineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China;College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China;State Key Laboratory Base for Eco-chemical Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China)

机构地区：[1]青岛科技大学海洋科学与生物工程学院,山东青岛266042 [2]青岛科技大学化学与分子工程学院,山东青岛266042 [3]青岛科技大学省部共建生态化工国家重点实验室培育基地,山东青岛266042

出　　处：《日用化学工业》2022年第5期476-485,共10页China Surfactant Detergent & Cosmetics

基　　金：生态化工国家重点实验室培育基地开放基金项目(STHG202002)。

摘　　要：胶原蛋白是一类从动物组织中提取的兼具营养和生理调节功能的多肽混合物。因具有低免疫原性、生物相容性、生物可降解性等特性以及保湿、美白、抗皱防衰等美容功能和降血脂、补钙等保健功能,而且可以通过物理、化学和与高分子材料共混等改性方法赋予其特定功能性质,胶原蛋白在医学生物、化妆品、保健品和食品等多个领域得到广泛应用。本文阐述了胶原蛋白的来源、类型和结构,以及理化性质、制备方法、改性技术及其典型功能与应用情况,并展望了胶原蛋白今后的研究开发方向。Collagen peptide, one kind of polypeptides mixture with both nutrition and physiological regulation function, is extracted from animal tissues. Collagen peptide can be seen as a hydrolyzed product of collagen, the main protein in connective tissues of animal, but with different microstructure from that of collagen. The three peptide chains of collagen are connected by covalent bond and hydrogen bond, and the three-strand helix structure remains intact, while the three-strand helix structure of collagen is completely loosened to form three unconnected single peptide chains as for collagen peptide. For possessing a large amount of excellent properties, such as low immunogenicity, biocompatibility, hemostatis, biodegradability, nutrition, moisture retention, skin whitening, anti-wrinkle, anti-aging, lipid-lowering, helpful to calcium-filling, as well as more powerful function could be obtained by physical, chemical modification and blending with natural and synthetic polymers. Collagen peptide has been extensively utilized in medicine, biology, cosmetics, health care industry, food and other fields. In this paper, the extracting source, type and molecular structure of collagen peptide, the physical and chemical properties, extracting methods, main modification technologies of collagen peptide, as well as its main functions and applications were introduced. The research trend and development prospect of collagen peptide were also pointed out.

关 键 词：胶原蛋白 胶原 结构 性质 制备 改性 应用 

分 类 号：TQ658[化学工程—精细化工]