黄连上清胶囊联合抗敏牙膏治疗慢性牙周炎效果及对Th17/Treg、复发的影响  

Effect of Huanglian Shangqing Capsules combined with anti-allergic toothpaste in the treatment of chronic periodontitis

作　　者：蒋菁[1] 顾长明[1] Jing Jiang;Changming Gu(Tangshan Vocational&Technical College,Tangshan,Hebei 063000,China)

机构地区：[1]唐山职业技术学院,河北唐山063000

出　　处：《日用化学工业》2022年第5期539-544,共6页China Surfactant Detergent & Cosmetics

摘　　要：研究黄连上清胶囊联合高露洁专效抗敏牙膏治疗慢性牙周炎(CP)效果及对辅助性T细胞17/调节性T细胞(Th17/Treg)、复发的影响。选取CP患者134例,采用简单随机化法分为对照组(n=67)和观察组(n=67),分别给予高露洁专效抗敏牙膏、黄连上清胶囊+高露洁专效抗敏牙膏。观察两组治疗效果、不良反应、复发情况及治疗前后牙周袋深度(PD)、牙龈指数(GI)、龈沟出血指数(SBI)、吹气刺激敏感值(BST)、Th17/Treg细胞水平、牙龈卟啉单胞菌(PG)、乳酸杆菌(LB)。结果显示,治疗4周后,观察组治疗总有效率高于对照组(P<0.05);治疗4周后观察组PD、PLI、GI、BST值低于对照组(P<0.05);治疗4周后观察组Th17、Treg细胞及PG、LB水平低于对照组(P<0.05);两组不良反应及复发率比较差异无统计学意义(P>0.05)。黄连上清胶囊联合高露洁专效抗敏牙膏有利于下调CP患者Th17/Treg细胞水平,阻止细菌定植,改善牙周症状,提高治疗效果,且安全性高。The study aimed to investigate the effect of Huanglian Shangqing Capsule combined with Colgate special anti-allergic toothpaste on the treatment of chronic periodontitis(CP) and its effect on helper T cell 17/regulatory T cell(Th17/Treg) and recurrence. A total of 134 CP patients in the Hospital from October 2019 to October 2021 were selected and divided into the control group(n=67) and the observation group(n=67) by simple randomization, and were given Colgate special anti-allergic toothpaste and Shangqing Capsule+Colgate special anti-allergic toothpaste, respectively. The treatment effect, adverse reactions, recurrence, and periodontal pocket depth(PD), gingival index(GI), gingival crevicular bleeding index(SBI), insufflation sensitivity(BST), Th17/Treg cell levels, Porphyromonas gingivalis(PG), and Lactobacillus(LB) before and after treatment were observed in the two groups. After 4 weeks of treatment, the total effective rate of the observation group is higher than that of the control group(P<0.05). The PD, PLI, GI and BST values of the observation group are lower than those of the control group(P<0.05). The levels of Th17/Treg cells, PG and LB in the observation group are lower than those in the control group(P<0.05). There is no significant difference in adverse reactions and recurrence rates between the two groups(P>0.05). Huanglian Shangqing Capsules combined with Colgate anti-allergic toothpaste is beneficial to down-regulate the level of Th17/Treg cells in CP patients, prevent bacterial colonization, improve periodontal symptoms, and improve the therapeutic effect, and it has high safety.

关 键 词：牙膏 抗敏 慢性牙周炎 黄连上清胶囊 复发 

分 类 号：TQ658[化学工程—精细化工]