格列净联合胰岛素对脆性糖尿病血糖波动的影响研究  

Study of the Effect of Gliflozin Combined with Insulin on Blood Glucose Fluctuation in Brittle Diabetes Mellitus

作　　者：叶静思 游育东[1] 吴永和 YE Jingsi;YOU Yudong;WU Yonghe(Department of Endocrinology,the Second Hospital of Longyan City,Longyan,Fujian Province,364000 China)

机构地区：[1]龙岩市第二医院内分泌科,福建龙岩364000

出　　处：《糖尿病新世界》2022年第4期101-104,146,共5页Diabetes New World Magazine

摘　　要：目的研究胰岛素联合格列净在脆性糖尿病血糖患者临床治疗中的价值,为促进脆性糖尿病患者康复寻找有效措施。方法选择该院2020年6月—2021年10月收治的104例脆性糖尿病患者,采用随机数表法分组,每组52例。观察组患者接受格列净联合胰岛素治疗,对照组患者单纯接受胰岛素治疗,通过对比两组患者不同时间段的血糖水平、血糖波动、药物安全性。结果治疗7、14 d后,观察组患者空腹血糖分别为(7.46±0.87)、(6.25±0.50)mmol/L,明显低于对照组,差异有统计学意义(t=3.955、13.326,P<0.05);观察组治疗7、14 d餐后2 h血糖分别为(13.35±1.92)、(10.49±1.43)mmol/L,低于对照组,差异有统计学意义(t=9.094、9.947,P<0.05);观察组患者治疗7、14 d的最大血糖波动幅度分别为(8.07±1.25)、(6.33±0.75)mmol/L,低于对照组,差异有统计学意义(t=9.261、16.668,P<0.05)。观察组患者治疗7、14 d的餐后血糖波动幅度分别为(6.75±1.32)、(3.35±1.34)mmol/L,明显低于对照组,差异有统计学意义(t=6.564、8.103,P<0.05)。两组患者用药后的不良反应发生率比较,差异无统计学意义(P>0.05)。结论在脆性糖尿病患者临床治疗中,格列净联合胰岛素的治疗方法可以有效抑制患者的血糖波动,并促进患者血糖水平改善,具有满意的临床疗效,值得推广。Objective To study the clinical value of insulin combined with gliflozin in the clinical treatment of brittle diabetic patients with blood glucose,and to find effective measures for promoting the recovery of brittle diabetic patients.Methods A total of 104 patients with brittle diabetes who were admitted to the hospital from June 2020 to October 2021 were selected.After grouping by random number table method,52 cases in each group,the patients in the observation group received gliflozin combined with insulin therapy,and the patients in the control group received insulin therapy alone.By comparing the blood sugar levels,blood sugar fluctuations and drug safety of the two groups of patients in different time periods.Results After 7 d and 14 d of treatment,the fasting blood glucose in the observation group was(7.46±0.87)mmol/L and(6.25±0.50)mmol/L,which were significantly lower than those in the control group,and the difference was statistically significant(t=3.955,13.326,P<0.05);the 2 h postprandial blood glucose of the observation group 7 d and 14 d of treatment were(13.35±1.92)mmol/L and(10.49±1.43)mmol/L,respectively,which were lower than those in the control group,the difference was statistically significant(t=9.094,9.947,P<0.05);the maximum blood glucose fluctuation amplitudes in the observation group 7 d and 14 d of treatment were(8.07±1.25)mmol/L and(6.33±0.75)mmol/L,respectively,which were lower than those in the control group,and the differences were statistically significant(t=9.261,16.668,P<0.05).The postprandial blood glucose fluctuation amplitudes in the observation group 7 d and 14 d of treatment were(6.75±1.32)mmol/L and(3.35±1.34)mmol/L,which were significantly lower than those in the control group,and the difference was statistically significant(t=6.564,8.103,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion In the clinical treatment of patients with brittle diabetes,the treatment method

关 键 词：格列净 胰岛素 脆性糖尿病 血糖波动 不良反应 

分 类 号：R587.1[医药卫生—内分泌]