低热量饮食对肥胖型2型糖尿病(T2DM)患者胰岛素水平及胰岛素抵抗(IR)的影响  

The Effect of Low-calorie Diet on Insulin Level and Insulin Resistance(IR)in Obese Type 2 Diabetes(T2DM)Patients

作　　者：何晓汉 HE Xiaohan(Department of Endocrinology,Huaining County People's Hospital,Anqing,Anhui Province,246121 China)

机构地区：[1]怀宁县人民医院内分泌科,安徽安庆246121

出　　处：《糖尿病新世界》2022年第3期16-20,共5页Diabetes New World Magazine

摘　　要：目的评估低热量饮食对肥胖型2型糖尿病(T2DM)患者胰岛素水平及胰岛素抵抗(IR)的影响。方法选取2019年3月—2021年3月于该院行肥胖型2型糖尿病治疗的148例患者为研究对象。基于病床号抽签(单双号)规则均分为对照组和观察组,每组74例。对照组予常规饮食干预,观察组则予以低热量饮食干预。评估比对两组患者干预前后体质量水平、体质指数,空腹血糖、空腹胰岛素水平,总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平以及胰岛素抵抗指数。结果干预前,两组患者体质量、体质指数、空腹血糖、空腹胰岛素、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平以及胰岛素抵抗指数比较,差异无统计学意义(P>0.05)。干预后,观察组患者体质量、体质指数、空腹血糖以及空腹胰岛素水平均明显低于对照组,差异有统计学意义(P<0.001);总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平均明显优于对照组,差异有统计学意义(P<0.001);胰岛素抵抗指数明显低于对照组,差异有统计学意义(P<0.001)。结论相较于常规饮食方式,低热量饮食对肥胖型2型糖尿病(T2DM)患者胰岛素水平及胰岛素抵抗(IR)具有良好的影响,能进一步降低患者的胰岛素水平,改善胰岛素抵抗指数。Objective To evaluate the effect of low-calorie diet on insulin levels and insulin resistance(IR)in obese type 2 diabetes(T2DM)patients.Methods A total of 148 patients with obese type 2 diabetes who were treated in the hospital from March 2019 to March 2021 were selected as the research objects.Based on the bed number drawing(single and even number)rules,they were divided into the control group and the observation group,with 74 cases in each group.The control group was given regular diet intervention,and the observation group was given low-calorie diet intervention.Assess and compare the body mass level,body mass index,the level of fasting blood glucose,fasting insulin,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,and insulin resistance index of the two groups before and after intervention.Results Before the intervention,there was no statistically significant difference between the two groups of body mass,body mass index,fasting blood glucose,fasting insulin,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol levels,and insulin resistance index(P>0.05).After the intervention,the body mass,body mass index,fasting blood glucose and fasting insulin level of the observation group were significantly lower than those of the control group,the difference was statistically significant(P<0.001);the levels of total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol were significantly better than those of the control group,the difference was statistically significant(P<0.001);the insulin resistance index was significantly lower than that of the control group,the difference was statistically significant(P<0.001).Conclusion Compared with the conventional diet,low-calorie diet has a good effect on the insulin level and insulin resistance(IR)of obese type 2 diabetes(T2DM)patients,which can further reduce the patient's insulin level and improve the insulin resistance index.

关 键 词：2型糖尿病 肥胖 低热量饮食 体质指数 胰岛素抵抗 

分 类 号：R59[医药卫生—内科学]