卵巢低反应患者IL28B-SNP、AMH、Sp17Ab与乙肝病毒易感关系  

Correlation between the levels of IL28B-SNP,AMH,and Sp17Ab of patients with poor ovarian response and their susceptibility of hepatitis B virus infection

作　　者：叶兆萍 陈冰 YE Zhaoping;CHEN Bing(People's Hospital of Rongchang District,Chongqing,402460)

机构地区：[1]重庆市荣昌区人民医院,402460

出　　处：《中国计划生育学杂志》2022年第2期375-378,共4页Chinese Journal of Family Planning

摘　　要：目的:分析卵巢低反应(POR)患者乙型肝炎病毒(HBV)感染与白细胞介素28B-SNP rs8099917(IL28B-SNP)、血清抗苗勒管激素(AMH)和精子蛋白17抗体(Sp17Ab)的相关性。方法:选择2018年12月-2021年2月本院收治确诊的POR合并HBV感染患者82例为感染组,未合并HBV感染POR患者93例为未感染组;采用PCR法检测血中IL28B rs8099917水平,酶联免疫吸附法检测血清中AMH和Sp17Ab水平;采用Spearman相关性检验分析IL28B-SNP、AMH、Sp17Ab与POR患者HBV感染关系,采用logistics回归模型分析影响POR患者HBV感染的危险因素。结果:感染组IL28B-SNP rs8099917的G占比(59.8%)高于对照组(37.6%),AMH(3.05±0.29ng/m)低于对照组(4.61±0.32ng/m),Sp17Ab(9.57±2.13 U/L)高于对照组(3.28±0.79 U/L)(均P<0.05);IL28B-SNP、Sp17Ab与POR患者HBV感染呈正相关,AMH与POR患者HBV感染呈负相关(P<0.05);IL28B-SNP rs8099917的G突变、低AMH和高Sp17Ab是导致POR患者HBV感染的危险因素(P<0.05)。结论:IL28B rs8099917 SNP的G突变、低AMH和高Sp17Ab是导致POR患者HBV感染的危险因素,提示临床加强筛查并及时干预。Objective:To analyze the correlation between the levels of IL28 B-SNP,AMH,and Sp17 Ab of patients with poor ovarian response(POR)and their susceptibility of hepatitis B virus(HBV)infection.Methods:82 patients with POR complicated with HBV infection were selected in observation group,and the patients with POR were selected in 93 control group from December 2018 to February 2021.The expression of IL28 B rs8099917 of the patients in the two groups was detected by PCR.The levels of serum AMH and Sp17 Ab of the patients in the two groups were detected by ELISA.Spearman correlation test was used to analyze the relationship between the levels of IL28 B-SNP,AMH,and Sp17 Ab of the patients with POR and their susceptibility of HBV infection.Logistic regression model was used to analyze the risk factors of HBV infection of the patients with POR.Results:The proportion of IL28 B-SNP rs8099917 G mutation(59.8%)of the patients in the observation group was significantly higher than that(37.6%)of the patients in the control group,and the AMH level(3.05±0.29 ng/m)of the patients in the observation group was significantly lower than that(4.61±0.32 ng/m)of the patients in the control group.The Sp17 Ab level(9.57±2.13 U/L)of the patients in the observation group was significantly higher than that(3.28±0.79 U/L)of the patients in the control group(all P<0.05).The levels of Il28 b-SNP and Sp17 Ab of the patients with POR were positively correlated with their HBV infection rate,while the AMH level of the patients with POR was negatively correlated with their HBV infection rate(P<0.05).The G mutation of IL28 B-SNP rs8099917,the low AMH level,and the high Sp17 Ab level of the patients with POR were the risk factors of their HBV infection(P<0.05).Conclusion:G mutation of IL28 B-SNP rs8099917,the low AMH level,and the high sp17 ab level of the patients with POR are the independent risk factors of their HBV infection.It is suggested to strengthen clinical screening and timely intervention of the patients with POR.

关 键 词：卵巢低反应 乙肝病毒感染 白细胞介素28B-SNP rs8099917 抗苗勒管激素 精子蛋白17抗体 危险因素 相关性 

分 类 号：R512.62[医药卫生—内科学] R711.75[医药卫生—临床医学]