MTHFR C677T位点基因多态性与子痫前期易感性、严重程度及母婴结局关系  

Relationship between gene polymorphism of MTHFR C677T locus of pregnant women and the susceptibility and severity of their preeclampsia and their maternal-infant outcomes

作　　者：王可欣 WANG Kexin(Mianyang Central Hospital,Mianyang,Sichuan Province,621000)

机构地区：[1]四川省绵阳市中心医院,621000

出　　处：《中国计划生育学杂志》2022年第2期443-447,452,共6页Chinese Journal of Family Planning

摘　　要：目的:分析5,10-亚甲基四氢叶酸还原酶(MTHFR) C677T位点基因多态性与子痫前期易感性、严重程度及母婴结局关系。方法:选取2018年12月-2020年3月于本院检查并住院分娩的子痫前期孕妇104例为子痫前期组,按病情严重程度为轻度组(83例)和重度组(21例),同期产前检查并住院分娩的健康孕妇88例为对照组,比较各组MTHFR C677T位点基因型频率和等位基因频率,并分析MTHFR C677T位点基因多态性与子痫前期易感性、严重程度及母婴结局关系。结果:子痫前期组MTHFR C677T位点TT基因型频率和T等位基因频率高于对照组,CC基因型频率和C等位基因频率低于对照组(均P<0.05),CT基因型频率与对照组比较无差异(P>0.05);MTHFR C677T位点基因多态性与子痫前期易感性有关(P<0.05),TT基因型孕妇子痫前期易感性比CT+CC基因型孕妇增加3.51倍(OR=3.506,95%CI:1.501~8.194);轻度组和重度组MTHFR C677T位点基因型频率和基因频率比较无差异(P>0.05);MTHFR C677T位点基因多态性与子痫前期严重程度无关(P>0.05);MTHFR C677T位点不同基因型对应的孕妇剖宫产、早产、产后出血、胎盘早剥发生率以及新生儿体质量、新生儿Apgar评分和新生儿窒息、宫内窘迫发生率比较无差异(P>0.05)。结论:MTHFR C677T位点基因多态性与子痫前期易感性有关,但与子痫前期严重程度及母婴结局无关。Objective: To analyze the relationship between gene polymorphism of polymorphism of 5,10-methylenetetra hydrofolate reductase(MTHFR) C677 T locus of pregnant women and the susceptibility and severity of their preeclampsia and their maternal-infant outcomes. Methods: 104 pregnant women with preeclampsia who were examined and hospitalized for delivery were selected in group A and were divided in 83 women with mild preeclampsia in group A1 and 21 women with severe preeclampsia in group A2 from December 2018 to March 2020. And 88 healthy pregnant women were selected in group B during the same time period. The genotype frequency and allele frequency of MTHFR C677 T locus of the women were compared among these groups. The relationship between the gene polymorphism of MTHFR C677 T locus of the women and their susceptibility and severity of preeclampsia and their maternal-infant outcomes was analyzed. Results: TT genotype frequency and T allele frequency of MTHFR C677 T locus of the women in group A were significantly higher than those of the women in group B, but CC genotype frequency and C allele frequency of MTHFR C677 T locus of the women in group A were significantly lower(all P<0.05), there was no significant difference in CT genotype frequency of MTHFR C677 T locus of the women between group A and group B(P>0.05). MTHFR C677 T gene polymorphism of the women was associated with their preeclampsia susceptibility(P<0.05). The preeclampsia susceptibility of the women with TT genotype increased 3.51 times of that of the women with CT+CC genotype(OR=3.506,95%CI:1.501-8.194).There were no significant differences in genotype frequency and gene frequency of MTHFR C677 Tlocus of the women between group A1 and group A2(P>0.05).MTHFR C677 Tgene polymorphism of the women was not associated with the severity of their preeclampsia(P>0.05).There were no significant differences in the incidences of cesarean section,premature delivery,postpartum hemorrhage,and placental abruption of the women,the values of neonatal body weight and

关 键 词：子痫前期 5 10-亚甲基四氢叶酸还原酶 基因多态性 母婴结局 易感性 疾病程度 

分 类 号：R714.244[医药卫生—妇产科学]