胎停育危险因素的meta分析  

Meta-analysis of risk factors related to embryo damage

作　　者：王松伟[1] 闫园园 孙涛[1] 李长东[1] WANG Songwei;YAN Yuanyuan;SUN Tao;Li Changdong(Beijing Obstetrics and Gynecology Hospital,Beijing Maternal and Child Health Care Hospital Affiliated to Capital Medical University,Beijing,100026;Aviation General Hospital)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院,100026 [2]航空总医院

出　　处：《中国计划生育学杂志》2022年第5期968-975,共8页Chinese Journal of Family Planning

基　　金：首都医科大学附属北京妇产医院/北京妇幼保健院,中青年学科骨干培养专项课题(FCYYHL201904)。

摘　　要：目的:利用meta分析的方法研究胎停育的危险因素,为胎停育的预防提供依据.方法:通过检索Pubmed、CNKI、万方等数据库,使用“胎停育”“胚胎停止发育”与“影响因素”“相关因素”“危险因素”等主题词组合进行检索,检索时间从建库至2021年6月1日.收集研究胎停育危险因素的病例对照研究,按照确定的纳排标准筛选文献,使用Revman5.3.0进行meta分析.结果:共纳入了30篇文献,共34848例,其中胎停育组9850例,对照组24998例.胎停育的危险因素为孕妇≥35岁(OR=1.65,95%CI1.25~2.17)、沙眼衣原体感染(OR=4.15,95%CI1.96~8.77)、解脲支原体感染(OR=8.15,95%CI3.46~19.19)、吸烟(OR=3.02,95%CI1.74~5.24)、饮酒(OR=4.97,95%CI3.92~6.30)、既往流产史(OR=5.59,95%CI3.19~9.51)、不良心理(OR=3.51,95%CI2.34,5.28)、不良环境(OR=4.36,95%CI2.08~9.17)、胎儿染色体异常(OR=5.83,95%CI4.36~7.78)等.而补充叶酸是胎停育的保护因素(OR=0.30,95%CI0.21~0.45).结论:胎停育的危险因素较多,早期识别、干预,有利于预防胎停育的发生,实现优生优育.Objective: To summarize the risk factors of embryo damage by meta-analysis, and to provide evidence for preventing embryo damage. Methods: The literatures were searched in the databases, such as Pubmed, CNKI,Wanfang, and other, till to June 1, 2021 by the key terms of "missed abortion", "embryonic cessation of development",and "influencing factors", "relevant factors", and "risk factors". The case-control studies about the risk factors of embryo damage were collected and were screened according to the determined inclusion and exclusion criteria. Meta-analysis was performed by Revman5.3.0. Results: A total of 30 studies with 34848 cases were enrolled, which included 9850 cases with embryo damage and 24998 without embryo damage. The risk factors of embryo damage were the age of pregnant women ≥35 years old(OR=1.65,95%CI 1.25-2.17),the chlamydial trachomatis infection(OR=4.15, 95%CI 1.96-8.77), the ureaplasma urealyticum infection(OR=8.15, 95%CI 3.46-19.19), the smoking(OR=3.02, 95%CI 1.74-5.24),the alcohol consumption(OR=4.97,95%CI 3.92-6.30),the previous abortion history(OR=5.59, 95%CI 3.19-9.51),the unhealthy emotions(OR=3.51, 95%CI 2.34-5.28),the bad environment(OR=4.36, 95%CI 2.08-9.17), and the fetal chromosome abnormality(OR=5.83, 95%CI 4.36-7.78), etc. While the folic acid supplementation was a protective factor of embryo damage(OR=0.30, 95%CI 0.21-0.45). Conclusion: There are many risk factors of embryo damage. Early identification and intervention for the pregnant women are conducive to prevent the occurrence of embryo damage, so as to realize the eugenics.

关 键 词：胎停育 危险因素 文献分析 预防 

分 类 号：R714.2[医药卫生—妇产科学]