血清PLGF、PAPP-A、β-HCG与妊娠期高血压疾病的相关性及预测不良妊娠结局价值  

Correlation between the levels of serum placental growth factor,pregnancy associated plasma protein-A,andβ-human chorionic gonadotropin of pregnant women and the occurrence of hypertensive disorder complicating pregnancy and their values for predicting the adverse pregnancy outcomes of the women

作　　者：刘佩琳 马丽丽 高万里 LIU Peilin;MA Lili;GAO Wanli(Copital Medical University Daxing Teaching Medicine,Beijing,102600)

机构地区：[1]首都医科大学大兴教学医院,102600

出　　处：《中国计划生育学杂志》2022年第5期1154-1158,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨孕妇胎盘生长因子(PLGF)、妊娠相关血浆蛋白-A(PAPP-A)、人绒毛膜促性腺激素(β-HCG)表达及与妊娠期高血压疾病的相关性.方法:选取2019年2月—2021年7月在本院建档并定期产前检查的妊娠期高血压疾病患者127例(病例组),分为妊娠期高血压组、子痫前期轻度组和子痫前期重度组,正常孕妇160例为对照组.采用酶联免疫吸附法检测血清PLGF、PAPP-A水平,全自动化学发光免疫分析仪检测血清β-HCG水平;Pearson法分析血清PLGF、PAPP-A、β-HCG与妊娠期高血压疾病患者不良妊娠结局的相关性,受试者工作特征曲线分析其预测不良妊娠结局价值,logistic回归分析发生影响因素.结果:妊娠高血压组、子痫前期轻度组、子痫前期重度组血清PAPP-A、β-HCG水平依次升高且均高于对照组,PLGF表达水平依次降低且均低于对照组(均P<0.05).病例组发生胎儿生长受限、胎儿窘迫、早产比例高于对照组(P<0.05);不良妊娠结局患者血清PLGF表达水平低于良好妊娠结局组,血清PAPP-A、β-HCG水平高于良好妊娠结局组(均P<0.05).血清PLGF水平与胎儿生长受限、胎儿窘迫、早产呈负相关,PAPP-A和β-HCG水平与胎儿生长受限、胎儿窘迫、早产均呈正相关(均P<0.05).血清PLGF、PAPP-A、β-HCG联合预测妊娠期高血压疾病患者不良妊娠结局发生的曲线下面积为0.929,且高于各指标单独预测(P<0.05).影响妊娠期高血压疾病患者不良妊娠结局发生,血清PLGF高表达是保护因素,血清PAPP-A、β-HCG高表达是独立危险因素.结论:妊娠期高血压疾病患者血清PLGF、PAPP-A、β-HCG表达异常且与不良妊娠结局发生相关,3项指标可作为评估妊娠期高血压不良妊娠结局的潜在生物学指标.Objective: To detect the expression of placental growth factor(PLGF),pregnancy associated plasma protein-A(PAPP-A), and β-human chorionic gonadotropin(β-HCG) of pregnant women, and to explore the correlation between the levels of PLGF, PAPP-A, β-HCG of the women and their occurrence of hypertensive disorder complicating pregnancy. Methods: From February 2019 to July 2021,127 pregnant women with hypertensive disorder complicating pregnancy who were registered and had accepted regular antenatal examination were selected in study group, and were divided into group A( women with pregnancy induced hypertension), group B( women with mild preeclampsia),and group C( women with severe preeclampsia). 160 normal pregnant women were selected in control group during the same period. Enzyme linked immunosorbent assay was used to detect the expression levels of serum PLGF and PAPP-A, and automatic chemiluminescence immunoassay analyzer was used to detected the serum level of β-HCG. Pearson method was used to analyze the correlation between the levels of serum PLGF,PAPP-A,β-HCG of the women with hypertensive disorder complicating pregnancy and their adverse pregnancy outcomes.Receiver operating characteristic(ROC)curve was used to analyze the value of the levels of serum PLGF,PAPP-A,β-HCG of the women for predicting their adverse pregnancy outcomes,and Logistic regression analysis was used to analyze the related factors affecting the adverse pregnancy outcomes.Results:The levels of PAPP-A andβ-HCG of the women in group A,group B,and group C had increased gradually,and which were significantly higher than those of the women in the control group.The level of PLGF of the women in group A,group B,and group C had decreased gradually,and which was significantly lower than that of the women in the control group(all P<0.05).The rates of fetal growth restriction,fetal distress,and preterm delivery of the women in the study group were significantly higher than those of the women in the control group(P<0.05).The serum PLGF level of

关 键 词：妊娠期高血压疾病 胎盘生长因子 妊娠相关血浆蛋白-A 人绒毛膜促性腺激素 不良妊娠结局 预测 影响因素 

分 类 号：R714.246[医药卫生—妇产科学]