O型血孕妇血清IgG抗A(B)抗体效价预测新生儿溶血病价值  

Value of serum IgG anti-A(B)antibody titer of pregnant women with blood type O for predicting the hemolytic disease of newborn

作　　者：符明昌 周莲 蔡添娥 武翔佳 郑泽强 FU Mingchang;HOU Lian;CAI Tian'e;WU Xiangjia;ZHENG Zeqiang(Sanya Central Hospital,Sanya,Hainan Province,572000)

机构地区：[1]海南省三亚市中心医院,572000

出　　处：《中国计划生育学杂志》2022年第5期1171-1173,共3页Chinese Journal of Family Planning

摘　　要：目的:分析O型血孕妇血清免疫球蛋白G(IgG)抗A(B)抗体效价对新生儿溶血病(HDN)诊断价值.方法:选取2016年12月—2020年12月本院收治的O型血孕妇385例,采用抗球蛋白检测孕妇血清IgG抗A(B)抗体效价,并对新生儿进行HDN血清学检测,采用受试者工作特征(ROC)曲线分析O型血孕妇血清IgG抗A(B)抗体效价对HDN的预测价值.结果:385例O型血孕妇中,血清IgG抗A(B)抗体效价≤1:32、1:64、1:128、1:256、≥1:512分别为17.7%、27.0%、21.8%、18.7%、14.8%.O-A血型孕妇血清IgG抗A(B)抗体效价≥1:512占比高于O-B及O-AB血型孕妇(P<0.05),O-A、O-B及O-AB血型孕妇新生儿HDN阳性率无差异(P>0.05).血清IgG抗A(B)抗体效价≥1:512孕妇新生儿HDN发生率与效价1:256无差异,但均高于≤1:32、1:64、1:128的HDN发生率,效价≤1:32、1:64、1:128孕妇新生儿HDN发生率依次升高(P<0.05).ROC曲线分析显示,O型血孕妇血清IgG抗A(B)抗体效价预测新生儿发生HDN的敏感度为96.0%,特异度为68.0%,AUC为0.848.结论:O型血孕妇血清IgG抗A(B)抗体效价对新生儿发生HDN预测价值较高,可作为临床早期干预参考指标.Objective: To study the value of serum immunoglobulin G(IgG) anti-A(B) antibody titer of pregnant women with blood type O for predicting the hemolytic disease of newborn(HDN). Methods: 385 pregnant women with blood type O were selected as the study subjects from December 2016 to December 2020. Antiglobulin detection was used to detect serum IgG anti-A(B)antibody titer of these women, and serological test for HDN was performed in the newborns of these women. Receiver operating characteristic(ROC)curve was used to analyze the value of serum IgG anti-A(B)antibody titer of the women for predicting their HDN. Results: In the 385 pregnant women with blood type O, the proportions of their serum IgG anti-A(B) antibody titers ≤1:32, 1:64, 1:128, 1:256, ≥ 1:5152 were 17.7%, 27.0%, 21.8%, 18.7%, 14.8%, respectively. The proportion of IgG anti-A(B) antibody titer ≥1:512 of the pregnant women with blood type O-A was significantly higher than that of the pregnant women with blood type O-B and O-AB(P<0.05), and there was no significant difference in the positive rate of HDN among the women with blood type O-A, O-B, and O-AB(P>0.05). The incidence of HDN in the pregnant women with serum IgG anti-A(B) antibody titer ≥ 1:512 had no significant different from that of the pregnant women with serum IgG anti-A(B) antibody titer 1:256, but which was significantly higher than that of the pregnant women with serum IgG anti-A(B) antibody titer ≤1:32, 1:64, or 1:128. The incidence of HDN in the pregnant women with serum IgG anti-A(B) antibody titer ≤1:32, 1:64, 1:128 had increased gradually(P<0.05). ROC curve analysis showed that the sensitivity, the specificity, and the area under curve of the serum IgG anti-A(B) antibody titer for predicting the HDN were 96.0%, 68.0%, and 0.848, respectively. Conclusion: The serum IgG anti-A(B)antibody titer of the pregnant women with blood type O for predicting their HDN occurrence has higher value,which maybe as a reference index for early intervention in clinic.

关 键 词：O型血孕妇 IgG抗A(B)抗体效价 新生儿溶血病 预测 

分 类 号：R446.6[医药卫生—诊断学] R722.18[医药卫生—临床医学]