干细胞治疗Asherman综合征的研究进展  

Research progress of stem cell for treating Asherman syndrome

作　　者：汪沙[1] 段华[1] WANG Sha;DUAN Hua(Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,100006)

机构地区：[1]首都医科大学附属北京妇产医院,100006

出　　处：《中国计划生育学杂志》2022年第5期1199-1203,1209,共6页Chinese Journal of Family Planning

基　　金：国家重点研发计划项目(2018YFC1004800)。

摘　　要：本文综述干细胞治疗Asherman综合征的最新证据.干细胞参与Asherman综合征相关生育力和纤维化方面的调控机制.干细胞通过归巢到损伤部位、分泌趋化因子募集其他细胞、调节免疫应答并发挥潜在抗菌活性、分化为终末细胞或增殖为子细胞等多重机制,发挥促进损伤子宫内膜修复及再生效应.本文还阐述的不同来源干细胞特性及给药方式的疗效,在啮齿类动物模型中,治疗性全身系统注射干细胞比直接宫内注射能更有效地再生子宫内膜;骨髓源性干细胞因其具备更广泛的分化潜能,比子宫源性干细胞在子宫再生方面的作用更强;此外,临床试验已经初步证明月经、骨髓、脐带和脂肪组织来源的干细胞在恢复月经、生育结局和子宫内膜再生方面均具有安全性和有效性.This article reviews the newest evidences of stem cell for treating Asherman syndrome.Stem cells are in-volved in the regulation of fertility and fibrosis related to Asherman syndrome.Stem cells can promote the repair and regeneration of damaged endometrium by multiple mechanism,such as homing to the injured site,recruiting other cells by secreting chemokines,regulating the immune response,and improving the potential antibacterial activity and differ-entiation into terminal cells or proliferation into daughter cells,etc.This article also discusses the different sources of stem cells and the curative effect of their ways of administration.In rodent models,the stem cells injecting in the whole body systemically can regenerate endometrium more effectively than that of intrauterine injection.The bone marrow-derived stem cells have wider differentiation potential,which play a stronger role in uterine regeneration than that of u-terine-derived stem cells.In addition,clinical trials have preliminarily demonstrated that the stem cells derived from menstruation,bone marrow,umbilical cord,or adipose tissue have the safety and the efficacy in the recovery of men-struation,the fertility outcomes,and the endometrial regeneration.

关 键 词：ASHERMAN综合征 宫腔粘连 干细胞 内膜再生 细胞归巢 

分 类 号：R711[医药卫生—妇产科学]