孕早期血清PAPP-A、PLGF、Hcy预测妊娠高血压发生风险  

Value of the serum pregnancy associated plasma protein A,placental growth factor,and homocysteine levels for predicting the risk of hypertension disease of pregnancy during the first trimester of pregnancy

作　　者：李美杰[1] 于峰[1] 周立岩[1] 阿艳妮 LI Meijie;YU Feng;ZHOU Liyan;A Yan(The Eighth People's Hospital of Qingdao,Shandong Province,266100;Qingdao Women and Children Hospital)

机构地区：[1]青岛市第八人民医院,266100 [2]青岛市妇女儿童医院

出　　处：《中国计划生育学杂志》2022年第4期914-917,共4页Chinese Journal of Family Planning

摘　　要：目的:分析孕早期母血清妊娠相关血浆蛋白A(PAPP-A)、胎盘生长因子(PLGF)、同型半胱氨酸(Hcy)与妊娠高血压疾病(HDP)的相关性及预测价值。方法:回顾性收集分析2017年6月-2020年6月于本院产科建档定期产前检查并分娩的HDP孕妇117例(HDP组)及单胎正常妊娠分娩孕妇50例(对照组)临床资料。分析孕10~13^(+6)周时血清PAPP-A、PLGF、Hcy水平及与HDP相关性和预测价值。结果:HDP组孕早期血清PAPP-A(27.56±6.03μmol/L)、PLGF(21.71±5.52ng/L)低于对照组(36.92±5.64μmol/L、40.69±8.63ng/L),Hcy(39.85±8.12μmol/L)高于对照组(11.75±2.31μmol/L),且均是HDP独立相关因素(均P<0.05);孕早期血清PAPP-A、PLGF、Hcy联合检测预测HDP临床价值最高,曲线下面积为0.864。结论孕早期血清PAPP-A、PLGF、Hcy表达水平与妊娠高血压有关,三者联合测定有助于对妊娠高血压的预测,对指导临床早期有计划地防治妊娠高血压有一定意义。Objective:To analyze the relationship between the levels of pregnancy associated plasma protein A(PAPPA),placental growth factor(PlGF),and homocysteine(Hcy)of pregnant women during the first trimester of pregnancy and their hypertension disease of pregnancy(HDP)occurrence,and to study the value of the levels of PAPP-A,PlGF,and Hcy for predicting HDP.Methods:The clinical data of 117pregnant women with HDP(in study group)and another 50normal pregnant women with singleton pregnancy(in control group)from June 2017to June 2020were collected retrospectively.The serum levels of PAPP-A,PLGF,and Hcy of the women in the two groups during 10-13^(+6) gestational weeks were analyzed.The relationship between the levels of PAPP-A,PLGF,and Hcy of the women and their HDP occurrence was analyzed.The values of the levels of PAPP-A,PLGF,and Hcy for predicting HDP were also analyzed.Results:The levels of serum PAPP-A(27.56±6.03μmol/l)and PLGF(21.71±5.52ng/l)of the women in the study group were significantly lower than those(36.92±5.64μmol/L and 40.69±8.63ng/l)of the women in the control group,but the Hcy level(39.85±8.12μmol/l)of the women in the study group was significantly higher than that(11.75±2.31μmol/l)of the women in the control group.The levels of PAPP-A,PLGF,and Hcy were the independent correlation factors of HDP(all P<0.05).The combined detection of the levels of serum PAPPA,PLGF,and Hcy had the highest clinical value for predicting HDP,and the area under the curve of which was 0.864.Conclusion:The expression levels of serum PAPP-A,PLGF,and Hcy of the pregnant women during the first trimester of pregnancy are related to their HDP occurrence.The combined detection of PAPP-A,PLGF and Hcy levels is helpful to predict HDP occurrence,and which has certain significance in guiding the early clinical prevention and treatment of HDP prepensely.

关 键 词：妊娠高血压 孕早期 妊娠相关血浆蛋白A 胎盘生长因子 同型半胱氨酸 预测 

分 类 号：R714.246[医药卫生—妇产科学]