产前多普勒超声参数与缺氧诱导因子-1α关系及诊断胎儿窘迫价值  

Correlation between the parameters measured by antenatal Doppler ultrasound of pregnant women with fetal distress and their level of hypoxia-inducible factor-1αand their values for diagnosing fetal distress

作　　者：姜海娜[1] 孙卓贵[1] 冯伶艳 JIANG Haina;SUN Zhigui;FENG Lingyan(Beichen District Hospital of traditional Chinese Medicine,Tianjin,300400;Daxing Teaching Hospital of Capital Medical University)

机构地区：[1]天津市北辰区中医医院,300400 [2]首都医科大学大兴教学医院

出　　处：《中国计划生育学杂志》2022年第4期932-935,共4页Chinese Journal of Family Planning

摘　　要：目的:分析产前多普勒超声参数与缺氧诱导因子-1α(HIF-1α)水平关系及对胎儿窘迫的诊断价值。方法:收集2019年11月-2020年11月本院就诊的疑似胎儿窘迫孕妇105例临床资料,以新生儿Apger评分分为胎儿窘迫组60例和非胎儿窘迫的对照组45例,对比两组多普勒超声参数脐动脉收缩与舒张压比值(S/D)、阻力指数(RI)、搏动指数(PI),分析各参数与促红细胞生成素(EPO)、β-人绒毛促性腺激素(β-HCG)的相关性及对胎儿窘迫的诊断价值。结果:S/D、RI、PI参数窘迫组高于对照组,且重度胎儿窘迫孕妇高于轻度胎儿窘迫孕妇;血清HIF-1α、EPO、β-HCG水平重度胎儿窘迫孕妇高于轻度胎儿窘迫孕妇(均P<0.05)。S/D、RI、PI、HIF-1α、EPO、β-HCG与胎儿窘迫程度相关,S/D、RI、PI与HIF-1α、EPO、β-HCG指标呈正相关(均P<0.05)。与S/D、RI、PI单项诊断相比,3项联合诊断胎儿窘迫最高(P<0.05),曲线下面积0.851,敏感度84.7%。结论:多普勒超声诊断胎儿窘迫价值较高,且参数S/D、RI、PI与血清HIF-1α、EPO、β-HCG相关,可为临床诊断提供帮助。Objective:To analyze the correlation between the parameters measured by antenatal Doppler ultrasound of pregnant women with fetal distress(FD)and their level of hypoxia-inducible factor-1α(HIF-1α),and to study the values of the parameters and the HIF-1αlevel for diagnosing FD of these women.Methods:The clinical data of 105pregnant women with suspected FD from November 2019to November 2020were collected.These women were divided into observation group(60women with FD)and control group(45women without FD)according to Apgar score of newborns.The values of the parameters measured by Doppler ultrasound,such as umbilical artery systolic to diastolic blood pressure(S/D),resistance index(RI),pulsatility index(PI),of the women were compared between the two groups.The relationship between the values of S/D,RI,and PI of the women and their erythropoietin(EPO)andβ-human chorionic gonadotropin(β-HCG)levels was analyzed.The values of S/D,RI,and PI,and the levels of EPO andβ-HCG for diagnosing FD were also analyzed.Results:The values of S/D,RI,and PI of the women in the observation group were significantly higher than those of the women in the control group,and which of the women with severe FD were significantly higher than those of the women with mild FD.The levels of serum HIF-1α,EPO,andβ-HCG of the women with severe FD were significantly higher than those of the women with mild FD(all P<0.05).The values of S/D,RI,and PI,and the levels of HIF-1α,EPO,andβ-HCG of the women were positively correlated with the degree of their FD,and the values of S/D,RI,and PI of the women were positively correlated with their HIF-1α,EPO,andβ-HCG levels(all P<0.05).The value of combined S/D,RI,and PI for diagnosing FD was significantly higher than that of the S/D value,the RI value,or the PI value alone(P<0.05),the area under the curve and the sensitivity of which were 0.851and 84.7%.Conclusion:Doppler ultrasound examination has a high diagnostic value for FD,and the S/D,RI,and PI values of the pregnant women with FD are related to th

关 键 词：胎儿窘迫 多普勒超声 缺氧诱导因子-1Α 促红细胞生成素 β-人绒毛促性腺激素 诊断价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]