暖宫孕子胶囊联合黄体酮治疗黄体功能不全不孕对子宫内膜厚度、炎症因子及妊娠结局效果  

Effects of Nuangong yunzi capsules combined with progesterone for treating infertility patients induced by luteal phase deficiency on their endometrial thickness,inflammatory factors,and pregnancy outcomes

作　　者：韦贞汁 权丽丽[1] 薛丽霞[1] 何秀梅 温瑜鹏[1] 张敏 白贞贞[1] 杨立 WEI Zhenzhi;QUAN Lili;XUE Lixia;HE Xiumei;WEN Yupeng;ZHANG Min;BAI Zhenzhen;YANG Li(Sanmenxia Central Hospital,Henan Province,472000;Zhengzhou Laboratory of edomelrial disease prevention and theatment)

机构地区：[1]河南省三门峡市中心医院,472000 [2]河南省郑州市子宫内膜疾病防治重点实验室

出　　处：《中国计划生育学杂志》2022年第3期520-523,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨暖宫孕子胶囊联合黄体酮治疗黄体功能不全所致不孕对患者子宫内膜厚度、炎症因子及妊娠结局的影响。方法:选取2018年6月-2021年6月于本院确诊为黄体功能不全所致不孕患者120例,随机对照原则分为对照组(58例)和观察组(62例),对照组采取黄体酮治疗,观察组在对照组基础上联用暖宫孕子胶囊治疗,比较两组治疗前后子宫内膜厚度、性激素和炎症因子水平、临床疗效和妊娠结局。结果:治疗后两组孕酮、雌二醇水平、子宫内膜厚度均高于治疗前,两组白细胞介素-2、肿瘤坏死因子-α水平均低于治疗前,且观察组改善程度优于对照组(均P<0.05);临床总有效率观察组(90.3%)高于对照组(70.7%),观察组排卵(90.3%)和妊娠成功率(59.7%)均高于对照组(58.6%、32.8%)(均P<0.05)。结论:对黄体功能不全所致不孕患者采取暖宫孕子胶囊和黄体酮联合治疗,能有效调节患者体内性激素水平和子宫内膜受容性,降低炎症因子水平,提高妊娠率。Objective: To explore the effects of Nuangong yunzi capsules combined with progesterone for treating infertility patients induced by luteal phase deficiency(LPD) on their endometrial thickness, inflammatory factors, and pregnancy outcomes.Methods: A total of 120 infertility patients induced by LPD were enrolled and divided into control group(58 cases) and observation group(62 cases) according to randomized control principle from June 2018 to June 2019.The patients in the control group were treated with progesterone, while the patients in the observation group were treated with Nuangong yunzi capsules combined with progesterone.The endometrial thickness, the levels of sex hormones and inflammatory factors, the clinical efficacy, and the pregnancy outcomes of the patients before and after treatment were compared between the two groups.Results: The levels of progesterone and estradiol, and the endometrial thickness of the patients in the two groups after treatment were significantly higher than those before treatment, but the levels of interleukin-2 and tumor necrosis factor-α of the patients in the two groups after treatment were significantly lower, and the improvement degree of which of the patients in the observation group was significantly better than that of the patients in the control group(all P<0.05).The total clinical effective rate(90.3%) of the patients in the observation group was significantly higher than that(70.7%) of the patients in the control group, the ovulation rate(90.3%) and the pregnancy success rate(59.7%) of the patients in the observation group were significantly higher than those(58.6% and 32.8%) of the patients in the control group(all P<0.05).Conclusion: Nuangong yunzi capsules combined with progesterone for treating infertility patients induced by luteal phase deficiency can effectively regulate theire levels of sex hormones and their endometrial receptivity,can reduce their levels of inflammatory factors,and can increase their pregnancy rate.

关 键 词：不孕 黄体功能不全 暖宫孕子胶囊 黄体酮 子宫内膜 炎症因子 临床效果 

分 类 号：R711.6[医药卫生—妇产科学]