加减苍附导痰汤治疗痰湿阻滞型无排卵性不孕症对患者性激素水平及卵巢动脉血流的影响  

Effect of modified Cangfudaotan decoction for treating women with phlegm-dampness blocking anovulatory infertility on their sex hormone level and ovarian artery blood flow indexes

作　　者：王心瑶 时磊[1] 董秀荣 WANG Xinyao;SHI Lei;DONG Xiurong(Tongzhou Branch of Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,101100)

机构地区：[1]北京中医药大学东直门医院通州院区,101100

出　　处：《中国计划生育学杂志》2022年第3期529-533,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨加减苍附导痰汤治疗痰湿阻滞型无排卵性不孕症对患者性激素水平及卵巢动脉血流的影响。方法:选择2018年5月-2020年5月本院就诊的痰湿阻滞型无排卵性不孕症患者96例为研究对象,随机数字表法分为对照组(予以枸橼酸氯米芬胶囊治疗)与观察组(对照组基础上加减苍附导痰汤治疗)各48例,对比两组治疗前、治疗1个及4个月经周期后的性激素、血流动力学指标,随访1年排卵及妊娠情况。结果:治疗1、4个周期,观察组雌二醇(E_(2))高于对照组,而卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH低于对照组,卵巢动脉收缩期最大血流速度(PSV)高于对照组、而阻力指数(RI)、搏动指数(PI)低于对照组(均P<0.05)。随访1年,排卵率观察组(83.3%)与对照组(75.0%)无差异,妊娠率观察组(50.0%)高于对照组(29.2%)(均P<0.05)。结论:加减苍附导痰汤治疗痰湿阻滞型无排卵性不孕症,能有效调节患者性激素水平及改善卵巢动脉血流,提高临床效果。Objective:To explore the effect of modified Cangfudaotan decoction for treating women with phlegm-dampness blocking anovulatory infertility on the levels of their sex hormone and ovarian artery blood flow indexes.Methods:96 women with anovulatory infertility due to phlegm-dampness blockade were selected as the research subjects,and these women were divided into control group and observation group(48 cases in each group)according to the random number table method.The women in the control group were given clomiphene citrate capsule,and the women in the observation group were given clomiphene citrate capsule combined with modified Cangfudaotan decoction.The levels of sex hormone and hemodynamic indexes of the women before treatment,in 1 and 4 menstrual cycles after treatment were compared between the two groups.The situations of ovulation and pregnancy of the women in the two groups were followed up for 1 year.Results:After 1 or 4 cycles of treatment,the level of estradiol(E_(2))of the women in the observation group was significantly higher than that of the women in the control group,while the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH),and the value of LH/FSH of the women in the observation group were significantly lower than those of the women in the control group.The maximum systolic blood flow velocity(PSV)value of ovarian artery of the women in the observation group was significantly higher than that of the women in the control group,while the values of resistance index(RI)and pulsatile index(PI)of ovarian artery of the women in the observation group were significantly lower than those of the women in the control group(all P<0.05).During 1 year followed up,there was no significant difference in ovulation rate(83.3%vs.75.0%)of the women between the two groups.The pregnancy rate(50.0%)of the women in the observation group was significantly higher than that(29.2%)of the women in the control group(P<0.05).Conclusion:Cangfudaotan decoction for treating infertility women with phlegm-damp bl

关 键 词：无排卵性不孕症 苍附导痰汤 痰湿阻滞型 性激素 卵巢动脉血流 

分 类 号：R271.14[医药卫生—中医妇科学]