散结镇痛胶囊联合屈螺酮炔雌醇片治疗子宫腺肌症对卵巢储备功能及血管生成因子水平影响  

Effect of Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets for treating patients with adenomyosis on their ovarian reserve and their levels of vascular endothelial growth factor,adiponectin,and angiopoietin-2

作　　者：潘鑫 李珉[1] PAN Xin;LI Min(The First Affiliated Hospital of Soochow University,Jiangsu Province,235000)

机构地区：[1]苏州大学附属第一医院,235000

出　　处：《中国计划生育学杂志》2022年第3期534-537,541,共5页Chinese Journal of Family Planning

基　　金：江苏省妇幼保健协会科研项目(FYX202002);放射医学与辐射防护国家重点实验室(GZK1202131)。

摘　　要：目的:探讨散结镇痛胶囊联合屈螺酮炔雌醇片治疗子宫腺肌症(ADS)对患者卵巢储备功能、血管内皮生长因子(VEGF)、脂联素(APN)、血管生成素-2(Ang-2)水平的影响。方法:选取本院2019年2月1日-2021年2月1日收治的ADS患者180例,随机分为中医组、西医组和中西医组各60例,分别给予散结镇痛胶囊、屈螺酮炔雌醇片-Ⅱ及结镇痛胶囊+屈螺酮炔雌醇片-Ⅱ治疗。比较治疗前后子宫体积、卵巢储备功能激素指标及血管生成相关因子水平。结果:治疗后,3组子宫体积、抗苗勒管激素、促卵泡激素、黄体生成素、雌激素、VEGF、APN均有不同程度降低,Ang-2水平不同程度升高,但中西医组变化幅度大于另外两组(均P<0.05)。治疗总有效率中西医组(83.3%)大于中医组(66.7%)和西医组(65.0%),3组治疗期间均未出现明显不良反应。结论:散结镇痛胶囊联合屈螺酮炔雌醇片治疗ADS,可有效改善患者卵巢储备功能、子宫状况和临床症状,降低血清VEGF、Ang-2水平,升高APN水平,疗效更佳,安全性较好。Objective:To explore the effect of Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets for treating patients with adenomyosis(ADS)on their ovarian reserve and their levels of vascular endothelial growth factor(VEGF),adiponectin(APN),and angiopoietin-2(Ang-2).Methods:180 patients with ADS were selected and were randomly divided into 3 groups(60 cases in each group)from February 2019 to February 2021.The patients in group 1 had received Sanjie zhentong capsules,the patients in group 2 had received drospirenone and ethinyl estradiol tablets-Ⅱ,and the patients in group 3 had received Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets-Ⅱ.The uterine volume,the levels of hormone indictors of ovarian reserve function and angiogenesis related factors of the patients were compared among the three groups.Results:After treatment,the uterine volume,the levels of antimullerian hormone,follicle-stimulating hormone,luteinizing hormone,estrogen,VEGF,and APN of the patients in the three groups had decreased to different degrees,while the Ang-2 level of the patients in the three groups had increased to different degrees,the change ranges of which of the patients in group 3 were significantly more than those of the patients in the other two groups(all P<0.05).The total effective rate(83.3%)of the patients in group 3 after treatment was significantly higher than that(66.7%)of the patients in group 1 and that(65.0%)of the patients in group 2.There was no any patient with obvious adverse reaction in the three groups.Conclusion:Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets for treating the patients with adenomyosis can effectively improve their ovarian reserve,can reduce their levels of VEGF and Ang-2,and can increase their APN level with better effectiveness and safety.

关 键 词：子宫腺肌症 屈螺酮炔雌醇片 散结镇痛胶囊 卵巢储备功能激素指标 血管生成因子 子宫体积 

分 类 号：R711.71[医药卫生—妇产科学]