不同水平血清载脂蛋白A1、B的不育患者精液质量分析  

Analysis of semen quality of infertile male patients with different serum apolipoprotein A1 and B levels

作　　者：黄鑫 孙博 马婧 王树松[1,2,3] HUANG Xin;SUN Bo;MA Jing;WANG Shusong(School of Chemistry and Materials Science,Hebei Normal University,Shijiazhuang,Hebei Province,050024;Graduate School of Hebei Medical University;Hebei Research Institutef or Family Planning Science and Technology(NHC Key Laboratory of Family Planning and Healthy,Hebei Key Laboratory of Reproductive Medicine))

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050024 [2]河北医科大学研究生学院 [3]河北省计划生育科学技术研究院/国家卫生健康委计划生育与优生重点实验室/河北省生殖医学重点实验室

出　　处：《中国计划生育学杂志》2022年第3期609-613,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨男性不育患者血清载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoB/ApoA1与精液质量的关系。方法:选取不育男性患者889例,检测其精液参数和血清ApoA1、ApoB水平,计算ApoB/ApoA1。分析精液参数与血清ApoA1、ApoB、ApoB/ApoA1的关系。结果;按ApoA1水平用四分位法分组后,精子浓度和精子总数的比较中,Q1组(ApoA1<1.19g/L)最高,Q2组(1.19g/L≤ApoA1<1.29g/L)最低(P<0.05)。按ApoB水平用四分位法分组后,Q2组(0.78≤ApoB<0.87g/L)精子浓度和精子总数均高于其他3组(P<0.05)。将所有对象分别按血清ApoA1、ApoB、ApoB/ApoA1临床标准分为正常组和异常组。其中血清ApoB正常组(ApoB 1.05~1.75g/L)精子总数大于异常组(P<0.05);ApoB/ApoA1﹤1组精子总数大于ApoB/ApoA1≥1组(P<0.05)。结论:精子生成可能与血清ApoB、ApoB/ApoA1有关。Objective:To investigate the relationship between the levels of serum apolipoprotein A1(ApoA1)and apolipoproteinB(ApoB),and the value of ApoB/ApoA1 of infertility male patients and their semen quality.Methods:A total of 889 infertile male patients were selected to detect their semen parameters and their serum ApoA1 and ApoB levels,and their ApoB/ApoA1 value was calculated.The relationship between the semen parameters of the patients and their ApoA1 and ApoB levels,and value of ApoB/ApoA1 was analyzed.Results:After grouping by the quartile method of ApoA1 level,the density and total number of sperm of the patients in group Q1(patients with ApoA1 level<1.19 g/L)was the highest,while which of the patients in group Q2(patients with 1.19 g/L≤ApoA1 level<1.29 g/L)was the lowest(P<0.05).After grouping by the quartile method of ApoB level,the density and total number of sperm of the patients in group Q2(patients with 0.78≤ApoB<0.87 g/L)were significantly higher than those of the patients in the other three groups(P<0.05).Based on the clinical criteria of the ApoA1 and ApoB levels and the value of ApoB/ApoA1 of these patients,the total sperm number of the patients with normal ApoB1 level(1.05-1.75 g/L)was significantly higher than that of the patients with abnormal ApoB1 level(P<0.05),and the total sperm number of the patients with ApoB/ApoA1﹤1 was significantly higher than that of the patients with ApoB/ApoA1≥1(P<0.05).Conclusion:Spermatogenesis of the infertility male patients maybe correlated with their serum ApoB and ApoB/ApoA1 levels.

关 键 词：男性不育 精液分析 载脂蛋白A1 载脂蛋白B 

分 类 号：R698.2[医药卫生—泌尿科学]