妊娠期肝内胆汁淤积症者血清SULT2A1、PAC-1、TPO-Ab表达意义及预测价值  

Significance of the expression of serum sulfatyltransferase 2A1,platelet activating complex-1,and thyroid peroxidase antibody of pregnant women with intrahepatic cholestasis of pregnancy and their predictive value

作　　者：马晓丽[1] 蒋瑛[1] MA Xiaoli;JIANG Ying(Gansu Maternal and Child Health Care Hospital,Lanzhou,Gansu Province,730050)

机构地区：[1]甘肃省妇幼保健院,兰州730050

出　　处：《中国计划生育学杂志》2022年第3期695-698,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期肝内胆汁淤积症患者血清硫酸基转移酶2A1(SULT2A1)、血小板激活复合物-1(PAC-1)、甲状腺过氧化物酶抗体(TPOAb)表达意义及预测价值。方法:选择2019年1月-2019年12月本院治疗的妊娠期肝内胆汁淤积症患者84例(观察组),同期产前检查健康孕妇70例为对照组,分析血清SULT2A1、PAC-1、TPOAb水平变化及其预测疾病价值。结果:观察组血清SULT2A1水平(26.68±5.06μmol/L)低于对照组(45.84±7.15μmol/L),PAC-1(15.63±6.35)%、TPOAb(19.46±5.35 ng/L)水平高于对照组(2.52±0.87)%(9.65±1.25 ng/L),且观察组随疾病程度加重各指标水平变化幅度升高(P<0.05);受试者工作曲线分析显示,预测妊娠期肝内胆汁淤积症,血清SULT2A1曲线下面积(AUC)为0.803,灵敏度为83.6%,特异度为85.4%,截断值为34.449μmol/L;血清PAC-1 AUC为0.834,灵敏度为82.6%,特异度为88.5%,截断值为4.251%;血清TPOAb AUC为0.830,灵敏度为84.2%,特异度为86.6%,截断值为12.257 ng/L;二者联合检测灵敏度(93.4%)、特异度(94.3%)最高(P<0.05)。结论:血清SULT2A1、PAC-1、TPOAb在妊娠期肝内胆汁淤积症患者血清中表达异常,对于病情监测具有临床价值。Objective:To study the significance of the expression of serum sulfatyltransferase 2 A1(Sult2 A1),platelet activating complex-1(PAC-1),and thyroid peroxidase antibody(TPOAB)of pregnant women with intrahepatic cholestasis of pregnancy(ICP).Methods:84 pregnant women with ICP were selected in experimental group,and 70 healthy pregnant women who underwent physical examination were selected in control group from January 2019 to December 2019.The changes of serum levels of Sult2 A1,PAC-1,and TPOAb of the women and their value for predicting ICP were analyzed.Results:The serum SULT2 A1 level(26.68±5.06μmol/L)of the women in the experimental group was significantly lower than that(45.84±7.15μmol/L)of the women in the control group.The levels of PAC-1(15.63±6.35%)and TPOAb(19.46±5.35 ng/L)of the women in the experimental group were significantly higher than those(2.52±0.87%and 9.65±1.25 ng/L)of the women in the control group,and which variation range of the women in the experimental group had increased with the aggravation of ICP(P<0.05).Receiver operating characteristic curve analysis had showed that the AUC,the sensitivity,the specificity,and the cut-off value of the serum SULT2 A1 level for predicting ICP were 0.803,83.6%,85.4%,and 34.449μmol/L,respectively.The AUC,the sensitivity,the specificity,and the cut-off value of the serum PAC-1 level for predicting ICP were 0.834,82.6%,88.5%,and 4.251%,respectively.The AUC,the sensitivity,the specificity,and the cut-off value of the serum TPOAb level for predicting ICP were 0.830,84.2%,86.6%,and 12.257 ng/L,respectively.The sensitivity(93.4%)and the specificity(94.3%)of the combination of levels the serum SULT2 A1,PAC-1,and TPOAb for predicting ICP were the highest(P<0.05).Conclusion:The expressions of serum SULT2 A1,PAC-1,and TPOAb of the pregnant women with ICP are abnormal,which have some clinical values for illness monitoring of ICP.

关 键 词：妊娠期肝内胆汁淤积症 硫酸基转移酶2A1 血小板激活复合物-1 甲状腺过氧化物酶抗体 预测价值 

分 类 号：R714.255[医药卫生—妇产科学]