胎儿生长受限孕妇子宫动脉、脐动脉血流指数与妊娠相关血浆蛋白关系及预测效能  

Correlation between the blood flow index of uterine artery and umbilical artery of pregnant women with fetal growth restriction and their pregnancy associated plasma protein level and their predictive efficacy

作　　者：陈瑶[1] 俞海平 王永红[1] CHEN Yao;YU Haiping;WANG Yonghong(The First People’s Hospital of Chenzhou,Hunan Province,423000)

机构地区：[1]湖南省郴州市第一人民医院,423000

出　　处：《中国计划生育学杂志》2022年第3期703-706,共4页Chinese Journal of Family Planning

摘　　要：目的:探究孕妇妊娠相关血浆蛋白(PAPP-A)与子宫动脉、脐动脉血流指数预测胎儿生长受限(FGR)价值。方法:选取2018年6月-2021年6月本院诊断疑似FGR孕妇110例,最终确诊FGR 60例为观察组(严重FGR 29例、FGR 31例),余50例为对照组,均行彩色多普勒超声诊断检测,酶联免疫吸附试验法检测血清PAPP-A水平。比较两组子宫动脉和脐动脉血流参数,分析患者子宫动脉、脐动脉血流参数与血清指标水平相关性及诊断价值。结果:观察组子宫动脉及脐动脉血流参数阻力指数(RI)、搏动指数(PI)、收缩期峰值流速/舒张末期流速(S/D)值均高于对照组且严重FGR患者更高,严重FGR者PAPP-A水平低于FGR者(均P<0.05);观察组子宫动脉、脐动脉血流参数RI、PI和S/D与病情严重程度呈正相关,PAPP-A与病情严重程度呈负相关,RI、PI、S/D与PAPP-A水平均呈负相关(均P<0.05);子宫动脉、脐动脉血流参数对FGR有诊断效能,各指标联合诊断效能最高(AUC=0.924)(P<0.05),灵敏度81.3%,特异度80.4%。结论:子宫动脉、脐动脉血流参数,以及血清PAPP-A水平与FGR病情程度具有相关性,子宫动脉、脐动脉血流参数对FGR有一定诊断价值。Objective: To explore the value of pregnancy-associated plasma protein A(PAPP-A) and the blood flow index of uterine artery and umbilical artery of pregnant women for predicting fetal growth restriction(FGR). Methods: 110 pregnant women with suspect FGR were selected in this study from June 2018 to June 2021. Among them, 60 women with confirmed FGR were in observation group(29 women with severe FGR in group A and 31 women with mild FGR in group B), and the other 50 women were in control group. All these women were examinated by color Doppler ultrasonography. The level of PAPP-A of these women were detected by enzyme-link immunosorbent assay(ELISA). The blood flow parameters of uterine artery and umbilical artery of the women were compared between the two groups. The correlation between the blood flow parameters of uterine artery and umbilical artery of the women and their serum indexes levels, as well as the correlation between the blood flow parameters and the serum indexes levels of the women and their disease severity, and the diagnostic value of the blood flow parameters and the serum indexes levels for diagnosing FGR were analyzed. Results: The values of resistance index(RI), pulsatile index(PI), and peak systolic flow rate/end diastolic flow rate(S/D) of the uterine and umbilical artery blood flow parameters of the women in the observation group were significantly higher than those of the women in the control group, and the values of RI, PI, and S/D of the women with severe FGR were significantly higher than those of the women with mild FGR,but the level of PAPP-A of the women with severe FGR was significantly lower(all P<0.05). The RI, PI, and S/D values of blood flow parameters of uterine artery and umbilical artery of the women with FGR were positively correlated with their severity of FGR. The level of PAPP-A of the women with FGR was negatively correlated with their severity of FGR. The values of RI, PI, and S/D of the women with FGR were negatively correlated with their PAPP-A level(all P<0.05).The va

关 键 词：胎儿生长受限 子宫动脉血流 脐动脉血流 妊娠相关血浆蛋白 相关性 预测 

分 类 号：R714.5[医药卫生—妇产科学]