血小板-淋巴细胞比值与系统性红斑狼疮疾病活动度的相关性研究  

Correlation between Platelet Lymphocyte Ratio and Disease Activity of Aystemic Lupus Erythematosus

作　　者：古彦琴 马浩哲 丛珊 孟岩[1] 罗莉 GU Yanqin;MA Haozhe;CONG Shan(The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China)

机构地区：[1]新疆医科大学第一附属医院风湿免疫科,新疆乌鲁木齐830000 [2]不详

出　　处：《河北医学》2022年第5期740-745,共6页Hebei Medicine

基　　金：新疆维吾尔自治区自然科学基金,(编号:2020D01C265)。

摘　　要：目的:探讨初发初治系统性红斑狼疮(SLE)患者血小板-淋巴细胞比值(PLR)与疾病活动度的相关性。方法:选取572名初发初治SLE患者为SLE组,选取同时期572名健康体检者为健康对照组,根据SLE疾病活动性指数2000将SLE患者分为低度活动组(SLEDAI≤9分,n=294)和高度活动组(SLEDAI>9分,n=278),分别比较以上各组PLR值,并通过Spearman相关分析探讨PLR与SLE疾病活动度的相关性。结果:SLE患者的PLR显著高于健康对照组(P<0.05)。在SLE患者中,高度活动组PLR显著高于低度活动组(P<0.05)。PLR与SLEDAI评分(r=0.291,P<0.05)、红细胞沉降率(r=0.207,P<0.05)、C反应蛋白(r=0.302,P<0.05)、抗ds-DNA抗体(r=0.098,P<0.05)、24h尿蛋白(r=0.173,P<0.05)呈正相关,与补体C3(r=-0.257,P<0.05)、补体C4(r=-0.223,P<0.05)呈负相关。PLR预测SLE疾病高度活动的受试者工作特征曲线的曲线下面积为0.639(P<0.05),当最佳临界值为170时,灵敏度为58.3%,特异度为65.6%。结论:PLR可作为SLE疾病活动度的评价指标之一。Objective:To explore the correlation between platelet to lymphocyte ratio(PLR)and disease activity in patients with systemic lupus erythematosus(SLE)during the first episode and initial treatment.Methods:A total of 572 patients with first attack and initial treatment of SLE were enrolled as SLE group,and 572 healthy people during the same period were enrolled as healthy control group,according to SLE disease activity index 2000,SLE patients were divided into low activity group(SLEDAI≤9 points,n=294)and high activity group(SLEDAI>9 points,n=278),the PLR of the above groups were compared respectively,and spearman statistical analysis was performed to investigate the correlation between PLR and disease activity of SLE.Results:The PLR of SLE patients was significantly higher than that of healthy controls(P<0.05).In SLE patients,the PLR of the high activity group was significantly higher than that of the low activity group(P<0.05).PLR was positively correlated with SLEDAI score(r=0.291,P<0.05),Erythrocyte sedimentation rate(r=0.207,P<0.05),C-reactive protein(r=0.302,P<0.05),anti-ds-DNA antibody(r=0.098,P<0.05),24h urine protein(r=0.173,P<0.05),negatively correlated with complement C3(r=-0.257,P<0.05)and complement C4(r=-0.223,P<0.05).The area under the receiver operating characteristic curve of PLR for predicting the high activity of SLE is 0.639(P<0.05).When the optimal critical value was 170,the sensitivity was 58.3%and the specificity was 65.6%.Conclusion:PLR can be used as one of the evaluation indicators for disease activity of SLE.

关 键 词：血小板-淋巴细胞比值 系统性红斑狼疮 红细胞沉降率 

分 类 号：R59[医药卫生—内科学]